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- Publisher Website: 10.1002/adma.202206545
- Scopus: eid_2-s2.0-85144280113
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Article: A MgFe-LDH Nanosheet-Incorporated Smart Thermo-Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration
Title | A MgFe-LDH Nanosheet-Incorporated Smart Thermo-Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration |
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Authors | |
Keywords | bone regeneration controllable releases growth factors MgFe-LDH nanosheets thermo-sensitive hydrogels |
Issue Date | 2023 |
Citation | Advanced Materials, 2023, v. 35, n. 5, article no. 2206545 How to Cite? |
Abstract | Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart hydrogels with excellent gelation/mechanical properties as well as controllable GF releasing capability. Herein, the incorporation of bone morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) hydrogels loaded with platelet-derived growth factor-BB (PDGF-BB) to construct a smart injectable thermo-responsive hydrogel (denoted as CSP-LB), which can achieve a burst release of PDGF-BB and a sustained release of BMP-2, for highly efficient bone regeneration is reported. The incorporation of MgFe-LDH in CS hydrogel not only shortens the gelation time and decreases sol–gel transition temperature, but also enhances the mechanical property of the hydrogel. Because of the sequential release of dual-GFs and sustained release of bioactive Mg2+/Fe3+ ions, the in vitro experiments prove that the CSP-LB hydrogel exhibits excellent angiogenic and osteogenic properties compared with the CS hydrogel. In vivo experiments further prove that the CSP-LB hydrogel can significantly enhance bone regeneration with higher bone volume and mineral density than that of the CS hydrogel. This smart thermo-sensitive CSP-LB hydrogel possesses excellent gelation capability and angiogenic and osteogenic properties, thus providing a promising minimally invasive solution for bone defect treatment. |
Persistent Identifier | http://hdl.handle.net/10722/329905 |
ISSN | 2021 Impact Factor: 32.086 2020 SCImago Journal Rankings: 10.707 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lv, Zehui | - |
dc.contributor.author | Hu, Tingting | - |
dc.contributor.author | Bian, Yixin | - |
dc.contributor.author | Wang, Guanyun | - |
dc.contributor.author | Wu, Zhikang | - |
dc.contributor.author | Li, Hai | - |
dc.contributor.author | Liu, Xueyan | - |
dc.contributor.author | Yang, Shuqing | - |
dc.contributor.author | Tan, Chaoliang | - |
dc.contributor.author | Liang, Ruizheng | - |
dc.contributor.author | Weng, Xisheng | - |
dc.date.accessioned | 2023-08-09T03:36:20Z | - |
dc.date.available | 2023-08-09T03:36:20Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Advanced Materials, 2023, v. 35, n. 5, article no. 2206545 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | http://hdl.handle.net/10722/329905 | - |
dc.description.abstract | Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart hydrogels with excellent gelation/mechanical properties as well as controllable GF releasing capability. Herein, the incorporation of bone morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) hydrogels loaded with platelet-derived growth factor-BB (PDGF-BB) to construct a smart injectable thermo-responsive hydrogel (denoted as CSP-LB), which can achieve a burst release of PDGF-BB and a sustained release of BMP-2, for highly efficient bone regeneration is reported. The incorporation of MgFe-LDH in CS hydrogel not only shortens the gelation time and decreases sol–gel transition temperature, but also enhances the mechanical property of the hydrogel. Because of the sequential release of dual-GFs and sustained release of bioactive Mg2+/Fe3+ ions, the in vitro experiments prove that the CSP-LB hydrogel exhibits excellent angiogenic and osteogenic properties compared with the CS hydrogel. In vivo experiments further prove that the CSP-LB hydrogel can significantly enhance bone regeneration with higher bone volume and mineral density than that of the CS hydrogel. This smart thermo-sensitive CSP-LB hydrogel possesses excellent gelation capability and angiogenic and osteogenic properties, thus providing a promising minimally invasive solution for bone defect treatment. | - |
dc.language | eng | - |
dc.relation.ispartof | Advanced Materials | - |
dc.subject | bone regeneration | - |
dc.subject | controllable releases | - |
dc.subject | growth factors | - |
dc.subject | MgFe-LDH nanosheets | - |
dc.subject | thermo-sensitive hydrogels | - |
dc.title | A MgFe-LDH Nanosheet-Incorporated Smart Thermo-Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/adma.202206545 | - |
dc.identifier.scopus | eid_2-s2.0-85144280113 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | article no. 2206545 | - |
dc.identifier.epage | article no. 2206545 | - |
dc.identifier.eissn | 1521-4095 | - |
dc.identifier.isi | WOS:000899789500001 | - |