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Article: A gut-brain axis mediates sodium appetite via gastrointestinal peptide regulation on a medulla-hypothalamic circuit
Title | A gut-brain axis mediates sodium appetite via gastrointestinal peptide regulation on a medulla-hypothalamic circuit |
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Authors | |
Issue Date | 15-Feb-2023 |
Publisher | American Association for the Advancement of Science |
Citation | Science Advances, 2023, v. 9, n. 7 How to Cite? |
Abstract | Salt homeostasis is orchestrated by both neural circuits and peripheral endocrine factors. The colon is one of the primary sites for electrolyte absorption, while its potential role in modulating sodium intake remains unclear. Here, we revealed that a gastrointestinal hormone, secretin, is released from colon endocrine cells under body sodium deficiency and is indispensable for inducing salt appetite. As the neural substrate, circulating secretin activates specific receptors in the nucleus of the solitary tracts, which further activates the downstream paraventricular nucleus of the hypothalamus, resulting in enhanced sodium intake. These results demonstrated a previously unrecognized gut-brain pathway for the timely regulation of sodium homeostasis. |
Persistent Identifier | http://hdl.handle.net/10722/329155 |
ISSN | 2021 Impact Factor: 14.957 2020 SCImago Journal Rankings: 5.928 |
DC Field | Value | Language |
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dc.contributor.author | Liu, Yuchu | - |
dc.contributor.author | Wei, Ji An | - |
dc.contributor.author | Luo, Zhihua | - |
dc.contributor.author | Cui, Jing | - |
dc.contributor.author | Luo, Yifan | - |
dc.contributor.author | Mak, Sarah Oi Kwan | - |
dc.contributor.author | Wang, Siqi | - |
dc.contributor.author | Zhang, Fengwei | - |
dc.contributor.author | Yang, Yan | - |
dc.contributor.author | So, Kwok-Fai | - |
dc.contributor.author | Shi, Lingling | - |
dc.contributor.author | Zhang, Li | - |
dc.contributor.author | Chow, Billy Kwok Chong | - |
dc.date.accessioned | 2023-08-05T07:55:42Z | - |
dc.date.available | 2023-08-05T07:55:42Z | - |
dc.date.issued | 2023-02-15 | - |
dc.identifier.citation | Science Advances, 2023, v. 9, n. 7 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10722/329155 | - |
dc.description.abstract | <p>Salt homeostasis is orchestrated by both neural circuits and peripheral endocrine factors. The colon is one of the primary sites for electrolyte absorption, while its potential role in modulating sodium intake remains unclear. Here, we revealed that a gastrointestinal hormone, secretin, is released from colon endocrine cells under body sodium deficiency and is indispensable for inducing salt appetite. As the neural substrate, circulating secretin activates specific receptors in the nucleus of the solitary tracts, which further activates the downstream paraventricular nucleus of the hypothalamus, resulting in enhanced sodium intake. These results demonstrated a previously unrecognized gut-brain pathway for the timely regulation of sodium homeostasis.</p> | - |
dc.language | eng | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.ispartof | Science Advances | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | A gut-brain axis mediates sodium appetite via gastrointestinal peptide regulation on a medulla-hypothalamic circuit | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciadv.add5330 | - |
dc.identifier.scopus | eid_2-s2.0-85148114720 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 7 | - |
dc.identifier.eissn | 2375-2548 | - |
dc.identifier.issnl | 2375-2548 | - |