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- Publisher Website: 10.1111/ajco.13664
- Scopus: eid_2-s2.0-85123951992
- PMID: 35100476
- WOS: WOS:000748698300001
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Article: Asbestos-related lung cancer: Clinical characteristics and survival outcomes in an Australian cohort seeking workers compensation
Title | Asbestos-related lung cancer: Clinical characteristics and survival outcomes in an Australian cohort seeking workers compensation |
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Authors | |
Keywords | asbestos cancer risk factors carcinogenesis clinical epidemiology lung cancer |
Issue Date | 2022 |
Citation | Asia-Pacific Journal of Clinical Oncology, 2022, v. 18, n. 5, p. e448-e455 How to Cite? |
Abstract | Background and objectives: Due to difficulties in identifying sufficient-sized cohorts there remains uncertainty about prognostic and clinical differences that may be unique to asbestos-related lung cancer (ARLC). In this study, we use the Helsinki Criteria to define a group of ex-workers with lung cancer attributable to asbestos exposure and investigate differences that may exist. Methods: A total of 529 patients seeking workers’ compensation for their lung cancer were assigned to either ARLC or the non-ARLC based on parameters defined in the Helsinki Criteria. Clinical and survival details were collected and analyzed. Results: In our study population, ARLC patients were on average older (72.1 ± 7.8) than non-ARLC patients (66.5 ± 10.2, P < 0.001) and were more likely to be diagnosed as a result of incidental findings or screening program (P < 0.001). The groups were similar in terms of clinical characteristics with the only difference being that plaques were more prevalent among ARLC patients (P < 0.001). Differences were observed for median overall survival (OS), ARLC (9 months) and non-ARLC (13 months, P = 0.005), as well for treatment (P = 0.01). After adjusting for age, however, these differences disappeared. Conclusions: Age at diagnosis, pleural plaques, and asymptomatic presentation were the attributes that we identified as significantly different between asbestos-related cancer and other lung cancers. In this cohort, ARLC patients were older diagnosis and with worse overall survival. |
Persistent Identifier | http://hdl.handle.net/10722/326514 |
ISSN | 2023 Impact Factor: 1.4 2023 SCImago Journal Rankings: 0.531 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hyland, Rebecca A. | - |
dc.contributor.author | Chrzanowska, Agata | - |
dc.contributor.author | Hannaford-Turner, Kirsty | - |
dc.contributor.author | Davis, Alexander | - |
dc.contributor.author | Ke, Helen | - |
dc.contributor.author | Bradbury, Lauren | - |
dc.contributor.author | Nagrial, Adnan | - |
dc.contributor.author | McCaughan, Brian | - |
dc.contributor.author | Hui, Rina | - |
dc.contributor.author | van Zandwijk, Nico | - |
dc.contributor.author | Takahashi, Ken | - |
dc.contributor.author | Kao, Steven C. | - |
dc.date.accessioned | 2023-03-10T02:19:49Z | - |
dc.date.available | 2023-03-10T02:19:49Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Asia-Pacific Journal of Clinical Oncology, 2022, v. 18, n. 5, p. e448-e455 | - |
dc.identifier.issn | 1743-7555 | - |
dc.identifier.uri | http://hdl.handle.net/10722/326514 | - |
dc.description.abstract | Background and objectives: Due to difficulties in identifying sufficient-sized cohorts there remains uncertainty about prognostic and clinical differences that may be unique to asbestos-related lung cancer (ARLC). In this study, we use the Helsinki Criteria to define a group of ex-workers with lung cancer attributable to asbestos exposure and investigate differences that may exist. Methods: A total of 529 patients seeking workers’ compensation for their lung cancer were assigned to either ARLC or the non-ARLC based on parameters defined in the Helsinki Criteria. Clinical and survival details were collected and analyzed. Results: In our study population, ARLC patients were on average older (72.1 ± 7.8) than non-ARLC patients (66.5 ± 10.2, P < 0.001) and were more likely to be diagnosed as a result of incidental findings or screening program (P < 0.001). The groups were similar in terms of clinical characteristics with the only difference being that plaques were more prevalent among ARLC patients (P < 0.001). Differences were observed for median overall survival (OS), ARLC (9 months) and non-ARLC (13 months, P = 0.005), as well for treatment (P = 0.01). After adjusting for age, however, these differences disappeared. Conclusions: Age at diagnosis, pleural plaques, and asymptomatic presentation were the attributes that we identified as significantly different between asbestos-related cancer and other lung cancers. In this cohort, ARLC patients were older diagnosis and with worse overall survival. | - |
dc.language | eng | - |
dc.relation.ispartof | Asia-Pacific Journal of Clinical Oncology | - |
dc.subject | asbestos | - |
dc.subject | cancer risk factors | - |
dc.subject | carcinogenesis | - |
dc.subject | clinical epidemiology | - |
dc.subject | lung cancer | - |
dc.title | Asbestos-related lung cancer: Clinical characteristics and survival outcomes in an Australian cohort seeking workers compensation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/ajco.13664 | - |
dc.identifier.pmid | 35100476 | - |
dc.identifier.scopus | eid_2-s2.0-85123951992 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | e448 | - |
dc.identifier.epage | e455 | - |
dc.identifier.eissn | 1743-7563 | - |
dc.identifier.isi | WOS:000748698300001 | - |