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Article: Hepatitis B surface antigen prevalence and the rates of mother-to-child transmission of hepatitis B virus after the introduction of infant vaccination programs in South East Asia and Western Pacific regions: a systematic review
Title | Hepatitis B surface antigen prevalence and the rates of mother-to-child transmission of hepatitis B virus after the introduction of infant vaccination programs in South East Asia and Western Pacific regions: a systematic review |
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Authors | |
Keywords | Children Hepatitis B Immunization Mother-to-child transmission Seroprevalence |
Issue Date | 2022 |
Citation | International Journal of Infectious Diseases, 2022, v. 124, p. 65-75 How to Cite? |
Abstract | Objectives: Infant vaccination against the hepatitis B virus began in the World Health Organization South East Asia Region and the Western Pacific Region between 1983 and 2016. This systematic review examined the seroprevalence of hepatitis B surface antigen (HBsAg) in children and the rate of mother-to-child transmission (MTCT) in these regions between 1990 and 2020. Methods: MEDLINE and EMBASE were searched for articles published between January 1990 and September 2020, which reported seroprevalence of HBsAg in children aged 0-15 years and/or the rate of MTCT in the South East Asia Region and Western Pacific Region. A pragmatic review identified supporting information. This review was registered in the International Prospective Register of Systematic Reviews (#CRD42020211707). Results: Of 115 included studies, 77 (24 countries) reported HBsAg prevalence, and 38 (nine countries) reported MTCT. The seroprevalence of HBsAg ranged between 0.0% and 27.4%, with a decreasing trend over time in each country. MTCT rates were 0.0-5.2% in infants of mothers who are hepatitis B e antigen-negative and 2.7-53.0% in infants of mothers who are hepatitis B e antigen-positive. Conclusion: After the introduction of infant hepatitis B virus vaccination programs, the countries in South East Asia Region and Western Pacific Region observed a reduction in HBsAg seroprevalence in children. Nevertheless, the risk of MTCT persists, emphasizing the importance of antenatal screening to identify high-risk pregnancies. |
Persistent Identifier | http://hdl.handle.net/10722/324231 |
ISSN | 2021 Impact Factor: 12.074 2020 SCImago Journal Rankings: 1.278 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Marjenberg, Zoe | - |
dc.contributor.author | Wright, Ciara | - |
dc.contributor.author | Pooley, Nick | - |
dc.contributor.author | Cheung, Ka Wang | - |
dc.contributor.author | Shimakawa, Yusuke | - |
dc.contributor.author | Vargas-Zambrano, Juan C. | - |
dc.contributor.author | Vidor, Emmanuel | - |
dc.date.accessioned | 2023-01-13T03:02:23Z | - |
dc.date.available | 2023-01-13T03:02:23Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | International Journal of Infectious Diseases, 2022, v. 124, p. 65-75 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | http://hdl.handle.net/10722/324231 | - |
dc.description.abstract | Objectives: Infant vaccination against the hepatitis B virus began in the World Health Organization South East Asia Region and the Western Pacific Region between 1983 and 2016. This systematic review examined the seroprevalence of hepatitis B surface antigen (HBsAg) in children and the rate of mother-to-child transmission (MTCT) in these regions between 1990 and 2020. Methods: MEDLINE and EMBASE were searched for articles published between January 1990 and September 2020, which reported seroprevalence of HBsAg in children aged 0-15 years and/or the rate of MTCT in the South East Asia Region and Western Pacific Region. A pragmatic review identified supporting information. This review was registered in the International Prospective Register of Systematic Reviews (#CRD42020211707). Results: Of 115 included studies, 77 (24 countries) reported HBsAg prevalence, and 38 (nine countries) reported MTCT. The seroprevalence of HBsAg ranged between 0.0% and 27.4%, with a decreasing trend over time in each country. MTCT rates were 0.0-5.2% in infants of mothers who are hepatitis B e antigen-negative and 2.7-53.0% in infants of mothers who are hepatitis B e antigen-positive. Conclusion: After the introduction of infant hepatitis B virus vaccination programs, the countries in South East Asia Region and Western Pacific Region observed a reduction in HBsAg seroprevalence in children. Nevertheless, the risk of MTCT persists, emphasizing the importance of antenatal screening to identify high-risk pregnancies. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Infectious Diseases | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Children | - |
dc.subject | Hepatitis B | - |
dc.subject | Immunization | - |
dc.subject | Mother-to-child transmission | - |
dc.subject | Seroprevalence | - |
dc.title | Hepatitis B surface antigen prevalence and the rates of mother-to-child transmission of hepatitis B virus after the introduction of infant vaccination programs in South East Asia and Western Pacific regions: a systematic review | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.ijid.2022.09.003 | - |
dc.identifier.pmid | 36089151 | - |
dc.identifier.scopus | eid_2-s2.0-85138997980 | - |
dc.identifier.hkuros | 343355 | - |
dc.identifier.volume | 124 | - |
dc.identifier.spage | 65 | - |
dc.identifier.epage | 75 | - |
dc.identifier.eissn | 1878-3511 | - |
dc.identifier.isi | WOS:000876603500007 | - |