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- Publisher Website: 10.1016/j.actbio.2020.10.030
- Scopus: eid_2-s2.0-85094960268
- PMID: 33148429
- WOS: WOS:000602981500001
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Article: Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division
Title | Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division |
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Authors | |
Keywords | Strontium Stem cells Asymmetric cell division Osteogenic differentiation |
Issue Date | 2021 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat |
Citation | Acta Biomaterialia, 2021, v. 119, p. 432-443 How to Cite? |
Abstract | Strontium, a popular osteogenic component, has been incorporated into various types of orthopaedic biomaterials to enhance bone regeneration. Strontium performs dual effects in promoting bone formation and inhibiting bone resorption. Previous studies have focused on the effects of strontium ions (Sr2+) in regulating stem cell behavior to initiate regenerative capacity. However, its mechanisms for regulating the fate and homeostasis of stem cells have not been fully elucidated. In this study, the promotive effect of Sr2+ on the osteogenic differentiation of mesenchymal stem cells was confirmed both in vitro and in vivo. Interestingly, in response to Sr2+ treatment, stem cells performed asymmetric cell division to balance stemness maintenance and osteogenic differentiation. In initiating osteogenic differentiation, Sr2+ maintained more cells in the cell cycle by upregulating the population of S and G2/M phase cells, and this increase in the cell population contributed to enhanced osteogenic differentiation. The divided cells with different cell fates were observed, with one daughter cell maintained stemness, while the other committed to osteogenic lineage. Further investigation revealed that Sr2+ activated noncanonical Wnt signaling to regulate the expression and distribution of the Par complex, thus regulating cell division. As a result, the daughter cells committed to different cell fates due to the discriminately activation of osteogenic transcription factors caused by asymmetrically distributed Par3 and aPKC. The results of this study could facilitate the design of biomaterials for bone regeneration by providing a better understanding of cell fate determination regulated by strontium. |
Persistent Identifier | http://hdl.handle.net/10722/305220 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 1.925 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, Y | - |
dc.contributor.author | YUE, J | - |
dc.contributor.author | LIU, Y | - |
dc.contributor.author | WU, J | - |
dc.contributor.author | GUAN, M | - |
dc.contributor.author | CHEN, D | - |
dc.contributor.author | PAN, H | - |
dc.contributor.author | ZHAO, X | - |
dc.contributor.author | Lu, WW | - |
dc.date.accessioned | 2021-10-20T10:06:20Z | - |
dc.date.available | 2021-10-20T10:06:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Acta Biomaterialia, 2021, v. 119, p. 432-443 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305220 | - |
dc.description.abstract | Strontium, a popular osteogenic component, has been incorporated into various types of orthopaedic biomaterials to enhance bone regeneration. Strontium performs dual effects in promoting bone formation and inhibiting bone resorption. Previous studies have focused on the effects of strontium ions (Sr2+) in regulating stem cell behavior to initiate regenerative capacity. However, its mechanisms for regulating the fate and homeostasis of stem cells have not been fully elucidated. In this study, the promotive effect of Sr2+ on the osteogenic differentiation of mesenchymal stem cells was confirmed both in vitro and in vivo. Interestingly, in response to Sr2+ treatment, stem cells performed asymmetric cell division to balance stemness maintenance and osteogenic differentiation. In initiating osteogenic differentiation, Sr2+ maintained more cells in the cell cycle by upregulating the population of S and G2/M phase cells, and this increase in the cell population contributed to enhanced osteogenic differentiation. The divided cells with different cell fates were observed, with one daughter cell maintained stemness, while the other committed to osteogenic lineage. Further investigation revealed that Sr2+ activated noncanonical Wnt signaling to regulate the expression and distribution of the Par complex, thus regulating cell division. As a result, the daughter cells committed to different cell fates due to the discriminately activation of osteogenic transcription factors caused by asymmetrically distributed Par3 and aPKC. The results of this study could facilitate the design of biomaterials for bone regeneration by providing a better understanding of cell fate determination regulated by strontium. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat | - |
dc.relation.ispartof | Acta Biomaterialia | - |
dc.subject | Strontium | - |
dc.subject | Stem cells | - |
dc.subject | Asymmetric cell division | - |
dc.subject | Osteogenic differentiation | - |
dc.title | Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division | - |
dc.type | Article | - |
dc.identifier.email | Lu, WW: wwlu@hku.hk | - |
dc.identifier.authority | Lu, WW=rp00411 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.actbio.2020.10.030 | - |
dc.identifier.pmid | 33148429 | - |
dc.identifier.scopus | eid_2-s2.0-85094960268 | - |
dc.identifier.hkuros | 327520 | - |
dc.identifier.volume | 119 | - |
dc.identifier.spage | 432 | - |
dc.identifier.epage | 443 | - |
dc.identifier.isi | WOS:000602981500001 | - |
dc.publisher.place | Netherlands | - |