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Article: Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities

TitleImmunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities
Authors
Marciscano, AEHaimovitz-Friedman, ALee, PLTran, PTTomé, WAGuha, CKong, FMSSahgal, AEl Naqa, IRimner, AMarks, LBFormenti, SCDeWeese, TL
Issue Date2021
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 2021, v. 110 n. 1, p. 35-52 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ijrobp.2019.02.046
AbstractPreclinical evidence suggests that stereotactic body radiation therapy (SBRT) is immunomodulatory. Given the potential to augment local and systemic antitumor responses, there is significant interest in the combination of SBRT with various immunotherapies to improve clinical outcomes. Additional preclinical and clinical investigation will be needed to better understand the radiobiologic and immunologic mechanisms of this potential synergy and to define the most appropriate application of SBRT to optimize this complex yet promising partnership with immunotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/304951
ISSN
0360-3016
2021 Impact Factor: 8.013
2020 SCImago Journal Rankings: 2.117
ISI Accession Number ID
WOS:000717463600004

 

DC FieldValueLanguage
dc.contributor.authorMarciscano, AE-
dc.contributor.authorHaimovitz-Friedman, A-
dc.contributor.authorLee, PL-
dc.contributor.authorTran, PT-
dc.contributor.authorTomé, WA-
dc.contributor.authorGuha, C-
dc.contributor.authorKong, FMS-
dc.contributor.authorSahgal, A-
dc.contributor.authorEl Naqa, I-
dc.contributor.authorRimner, A-
dc.contributor.authorMarks, LB-
dc.contributor.authorFormenti, SC-
dc.contributor.authorDeWeese, TL-
dc.date.accessioned2021-10-05T02:37:35Z-
dc.date.available2021-10-05T02:37:35Z-
dc.date.issued2021-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2021, v. 110 n. 1, p. 35-52-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/304951-
dc.description.abstractPreclinical evidence suggests that stereotactic body radiation therapy (SBRT) is immunomodulatory. Given the potential to augment local and systemic antitumor responses, there is significant interest in the combination of SBRT with various immunotherapies to improve clinical outcomes. Additional preclinical and clinical investigation will be needed to better understand the radiobiologic and immunologic mechanisms of this potential synergy and to define the most appropriate application of SBRT to optimize this complex yet promising partnership with immunotherapy.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.titleImmunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities-
dc.typeArticle-
dc.identifier.emailKong, FMS: kong0001@hku.hk-
dc.identifier.authorityKong, FMS=rp02508-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2019.02.046-
dc.identifier.pmid30836168-
dc.identifier.scopuseid_2-s2.0-85064244901-
dc.identifier.hkuros326075-
dc.identifier.volume110-
dc.identifier.issue1-
dc.identifier.spage35-
dc.identifier.epage52-
dc.identifier.isiWOS:000717463600004-
dc.publisher.placeUnited States-

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