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Article: Direct ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling

TitleDirect ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling
Authors
Huang, YDENG, YZHANG, JMENG, LLi, X
Issue Date2021
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2021, v. 57 n. 31, p. 3769-3772 How to Cite?
DOI: http://dx.doi.org/10.1039/D1CC00961C
AbstractMembrane proteins are important drug targets; however, ligand discovery for membrane proteins is highly challenging due to their hydrophobic nature. We show that membrane proteins may be specifically labelled with a DNA tag by DNA-programmed affinity labelling (DPAL), thereby enabling the screening of chemical compounds against membrane proteins directly on live cells.
Persistent Identifierhttp://hdl.handle.net/10722/301512
ISSN
1359-7345
2021 Impact Factor: 6.065
2020 SCImago Journal Rankings: 1.837
ISI Accession Number ID
WOS:000640303200005

 

DC FieldValueLanguage
dc.contributor.authorHuang, Y-
dc.contributor.authorDENG, Y-
dc.contributor.authorZHANG, J-
dc.contributor.authorMENG, L-
dc.contributor.authorLi, X-
dc.date.accessioned2021-08-09T03:40:08Z-
dc.date.available2021-08-09T03:40:08Z-
dc.date.issued2021-
dc.identifier.citationChemical Communications, 2021, v. 57 n. 31, p. 3769-3772-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/301512-
dc.description.abstractMembrane proteins are important drug targets; however, ligand discovery for membrane proteins is highly challenging due to their hydrophobic nature. We show that membrane proteins may be specifically labelled with a DNA tag by DNA-programmed affinity labelling (DPAL), thereby enabling the screening of chemical compounds against membrane proteins directly on live cells.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp-
dc.relation.ispartofChemical Communications-
dc.titleDirect ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling-
dc.typeArticle-
dc.identifier.emailHuang, Y: huangyr0@hku.hk-
dc.identifier.emailLi, X: xiaoyuli@hku.hk-
dc.identifier.authorityLi, X=rp02080-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/D1CC00961C-
dc.identifier.pmid33730131-
dc.identifier.scopuseid_2-s2.0-85104183809-
dc.identifier.hkuros324091-
dc.identifier.volume57-
dc.identifier.issue31-
dc.identifier.spage3769-
dc.identifier.epage3772-
dc.identifier.isiWOS:000640303200005-
dc.publisher.placeUnited Kingdom-

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