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Conference Paper: Diffusion tensor MR imaging of treatment-induced white matter injury in childhood cancer survivors: clinical and translational studies.
Title | Diffusion tensor MR imaging of treatment-induced white matter injury in childhood cancer survivors: clinical and translational studies. |
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Authors | |
Issue Date | 2018 |
Publisher | Asian Biophysics Association. |
Citation | Asian Biophysics Association Symposium and Annual Meeting of the Australian Society for Biophysics, Melbourne, Australia, 2-6 December 2018 How to Cite? |
Abstract | Diffusion tensor MR imaging (DTI) is based on the diffusion of water molecules in the brain, and advantageous for evaluating white matter pathology as the diffusion process in white matter is highly
directional (anisotropic) due to axonal fibers running in parallel. We evaluated its novel role as a
marker for treatment-induced neurotoxicity in childhood cancer (medulloblastoma and acute lymphoblastic leukemia) survivors, and then performed translational studies using an animal model of
radiation-induced white matter injury to elucidate the histological correlates of the diffusion tensor
indices. We found DTI indices to be associated with known neurotoxicity risk factors, and neurocognitive scores in children. In translational studies, the longitudinal changes of DTI indices reflected the histopathological changes of myelination, axonal damage, astrogliosis and necrosis. Hence, our results support the use of DTI to probe white matter microstructure, and as a biomarker to monitor radiation-induced white matter damage. |
Description | Session: MRI&PET - no. 206 |
Persistent Identifier | http://hdl.handle.net/10722/299821 |
DC Field | Value | Language |
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dc.contributor.author | Khong, PL | - |
dc.date.accessioned | 2021-05-31T10:03:53Z | - |
dc.date.available | 2021-05-31T10:03:53Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Asian Biophysics Association Symposium and Annual Meeting of the Australian Society for Biophysics, Melbourne, Australia, 2-6 December 2018 | - |
dc.identifier.uri | http://hdl.handle.net/10722/299821 | - |
dc.description | Session: MRI&PET - no. 206 | - |
dc.description.abstract | Diffusion tensor MR imaging (DTI) is based on the diffusion of water molecules in the brain, and advantageous for evaluating white matter pathology as the diffusion process in white matter is highly directional (anisotropic) due to axonal fibers running in parallel. We evaluated its novel role as a marker for treatment-induced neurotoxicity in childhood cancer (medulloblastoma and acute lymphoblastic leukemia) survivors, and then performed translational studies using an animal model of radiation-induced white matter injury to elucidate the histological correlates of the diffusion tensor indices. We found DTI indices to be associated with known neurotoxicity risk factors, and neurocognitive scores in children. In translational studies, the longitudinal changes of DTI indices reflected the histopathological changes of myelination, axonal damage, astrogliosis and necrosis. Hence, our results support the use of DTI to probe white matter microstructure, and as a biomarker to monitor radiation-induced white matter damage. | - |
dc.language | eng | - |
dc.publisher | Asian Biophysics Association. | - |
dc.relation.ispartof | Asian Biophysics Association Symposium in conjunction with Australian Society for Biophysics Meeting, 2018 | - |
dc.title | Diffusion tensor MR imaging of treatment-induced white matter injury in childhood cancer survivors: clinical and translational studies. | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Khong, PL: plkhong@hku.hk | - |
dc.identifier.authority | Khong, PL=rp00467 | - |
dc.identifier.hkuros | 311372 | - |
dc.publisher.place | Australia | - |