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- Publisher Website: 10.1016/j.rbmo.2020.01.003
- Scopus: eid_2-s2.0-85079548804
- PMID: 32081542
- WOS: WOS:000519987700012
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Article: Systematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids
Title | Systematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids |
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Authors | |
Keywords | Fibroid ablation Myomectomy Pregnancy outcomes Ulipristal acetate Uterine artery embolization |
Issue Date | 2020 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.rbmojournal.com |
Citation | Reproductive BioMedicine Online, 2020, v. 40 n. 3, p. 429-444 How to Cite? |
Abstract | The aim of this study was to compare pregnancy outcomes after medical (ulipristal acetate [UPA]), surgical (myomectomy) and radiological (uterine artery embolization [UAE] or thermal ablation) therapy for fibroids in women. A systematic review was conducted and ScienceDirect, PubMed, Web of Science and Cochrane Library databases were thoroughly searched from 2000 to 2018. Only primary research was included with independent extraction of articles by two reviewers, using a standardized form. Data were available on 12 pregnancies after treatment with UPA, 1575 after myomectomy, 424 after UAE and 420 after fibroid ablation. Results after UPA therapy were not included in the statistical analysis owing to the limited number of cases; most were ongoing pregnancies. High rates of successful pregnancy were seen after myomectomy (75.6%) and fibroid ablation (70.5%), whereas pregnancies after UAE had the lowest live birth rates (60.6%) and highest miscarriage rates (27.4%) (both P < 0.001 versus other treatments). In conclusion, myomectomy is associated with better pregnancy outcomes than other fertility-preserving treatments for fibroids. At present, UPA is the only medical treatment for fibroids; however, the evidence on pregnancy outcome is limited. In the absence of randomized controlled trials, these data may be of benefit in advising patients about future pregnancy. |
Persistent Identifier | http://hdl.handle.net/10722/294301 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.214 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | KHAW, SC | - |
dc.contributor.author | ANDERSON, RA | - |
dc.contributor.author | Lui, MW | - |
dc.date.accessioned | 2020-11-23T08:29:25Z | - |
dc.date.available | 2020-11-23T08:29:25Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Reproductive BioMedicine Online, 2020, v. 40 n. 3, p. 429-444 | - |
dc.identifier.issn | 1472-6483 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294301 | - |
dc.description.abstract | The aim of this study was to compare pregnancy outcomes after medical (ulipristal acetate [UPA]), surgical (myomectomy) and radiological (uterine artery embolization [UAE] or thermal ablation) therapy for fibroids in women. A systematic review was conducted and ScienceDirect, PubMed, Web of Science and Cochrane Library databases were thoroughly searched from 2000 to 2018. Only primary research was included with independent extraction of articles by two reviewers, using a standardized form. Data were available on 12 pregnancies after treatment with UPA, 1575 after myomectomy, 424 after UAE and 420 after fibroid ablation. Results after UPA therapy were not included in the statistical analysis owing to the limited number of cases; most were ongoing pregnancies. High rates of successful pregnancy were seen after myomectomy (75.6%) and fibroid ablation (70.5%), whereas pregnancies after UAE had the lowest live birth rates (60.6%) and highest miscarriage rates (27.4%) (both P < 0.001 versus other treatments). In conclusion, myomectomy is associated with better pregnancy outcomes than other fertility-preserving treatments for fibroids. At present, UPA is the only medical treatment for fibroids; however, the evidence on pregnancy outcome is limited. In the absence of randomized controlled trials, these data may be of benefit in advising patients about future pregnancy. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.rbmojournal.com | - |
dc.relation.ispartof | Reproductive BioMedicine Online | - |
dc.subject | Fibroid ablation | - |
dc.subject | Myomectomy | - |
dc.subject | Pregnancy outcomes | - |
dc.subject | Ulipristal acetate | - |
dc.subject | Uterine artery embolization | - |
dc.title | Systematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids | - |
dc.type | Article | - |
dc.identifier.email | Lui, MW: ellenlui@hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.rbmo.2020.01.003 | - |
dc.identifier.pmid | 32081542 | - |
dc.identifier.scopus | eid_2-s2.0-85079548804 | - |
dc.identifier.hkuros | 319304 | - |
dc.identifier.volume | 40 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 429 | - |
dc.identifier.epage | 444 | - |
dc.identifier.isi | WOS:000519987700012 | - |
dc.publisher.place | United Kingdom | - |