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- Publisher Website: 10.1038/s41467-020-17986-9
- Scopus: eid_2-s2.0-85089933324
- PMID: 32843628
- WOS: WOS:000567537300011
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Article: A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2
Title | A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2 |
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Authors | |
Issue Date | 2020 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html |
Citation | Nature Communications, 2020, v. 11, article no. 4252 How to Cite? |
Abstract | The 2019 novel respiratory virus (SARS-CoV-2) causes COVID-19 with rapid global socioeconomic disruptions and disease burden to healthcare. The COVID-19 and previous emerging virus outbreaks highlight the urgent need for broad-spectrum antivirals. Here, we show that a defensin-like peptide P9R exhibited potent antiviral activity against pH-dependent viruses that require endosomal acidification for virus infection, including the enveloped pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), and the non-enveloped rhinovirus. P9R can significantly protect mice from lethal challenge by A(H1N1)pdm09 virus and shows low possibility to cause drug-resistant virus. Mechanistic studies indicate that the antiviral activity of P9R depends on the direct binding to viruses and the inhibition of virus-host endosomal acidification, which provides a proof of concept that virus-binding alkaline peptides can broadly inhibit pH-dependent viruses. These results suggest that the dual-functional virus- and host-targeting P9R can be a promising candidate for combating pH-dependent respiratory viruses. |
Persistent Identifier | http://hdl.handle.net/10722/293687 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 4.887 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhao, H | - |
dc.contributor.author | To, KKW | - |
dc.contributor.author | Sze, KH | - |
dc.contributor.author | Yung, TTM | - |
dc.contributor.author | Bian, M | - |
dc.contributor.author | Lam, H | - |
dc.contributor.author | Yeung, ML | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Chu, H | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2020-11-23T08:20:22Z | - |
dc.date.available | 2020-11-23T08:20:22Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Nature Communications, 2020, v. 11, article no. 4252 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293687 | - |
dc.description.abstract | The 2019 novel respiratory virus (SARS-CoV-2) causes COVID-19 with rapid global socioeconomic disruptions and disease burden to healthcare. The COVID-19 and previous emerging virus outbreaks highlight the urgent need for broad-spectrum antivirals. Here, we show that a defensin-like peptide P9R exhibited potent antiviral activity against pH-dependent viruses that require endosomal acidification for virus infection, including the enveloped pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), and the non-enveloped rhinovirus. P9R can significantly protect mice from lethal challenge by A(H1N1)pdm09 virus and shows low possibility to cause drug-resistant virus. Mechanistic studies indicate that the antiviral activity of P9R depends on the direct binding to viruses and the inhibition of virus-host endosomal acidification, which provides a proof of concept that virus-binding alkaline peptides can broadly inhibit pH-dependent viruses. These results suggest that the dual-functional virus- and host-targeting P9R can be a promising candidate for combating pH-dependent respiratory viruses. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2 | - |
dc.type | Article | - |
dc.identifier.email | Zhao, H: hjzhao13@hku.hk | - |
dc.identifier.email | To, KKW: kelvinto@hku.hk | - |
dc.identifier.email | Sze, KH: khsze@hku.hk | - |
dc.identifier.email | Lam, H: nayioh16@hku.hk | - |
dc.identifier.email | Yeung, ML: pmlyeung@hku.hk | - |
dc.identifier.email | Li, C: licun@hku.hk | - |
dc.identifier.email | Chu, H: hinchu@hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | Zhao, H=rp02653 | - |
dc.identifier.authority | To, KKW=rp01384 | - |
dc.identifier.authority | Sze, KH=rp00785 | - |
dc.identifier.authority | Yeung, ML=rp01402 | - |
dc.identifier.authority | Li, C=rp02783 | - |
dc.identifier.authority | Chu, H=rp02125 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-020-17986-9 | - |
dc.identifier.pmid | 32843628 | - |
dc.identifier.pmcid | PMC7447754 | - |
dc.identifier.scopus | eid_2-s2.0-85089933324 | - |
dc.identifier.hkuros | 318907 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 4252 | - |
dc.identifier.epage | article no. 4252 | - |
dc.identifier.isi | WOS:000567537300011 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-1723 | - |