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Article: HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues
Title | HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues |
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Authors | |
Issue Date | 2020 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/journals-books-databases/about-journals/organic-chemistry-frontiers/ |
Citation | Organic Chemistry Frontiers: an international journal of organic chemistry, 2020, v. 7 n. 8, p. 993-996 How to Cite? |
Abstract | In order to understand the production and functions of HOCl in biological systems, a sensitive and selective detection method is urgently needed, especially for HOCl visualization in living cells and tissues. Herein we report a highly sensitive and selective rhodol-based fluorescent probe HKOCl-4 for HOCl detection. HKOCl-4r and HKOCl-4m, which were designed for better cellular uptake and mitochondria-targeting, respectively, have been successfully applied in detecting endogenous HOCl in macrophages. Furthermore, HOCl production in ischemic rat brain tissues has been visualized with HKOCl-4r in a middle cerebral artery occlusion (MCAO) model. These probes would serve as powerful imaging tools for delving into the roles of HOCl in health and disease. |
Persistent Identifier | http://hdl.handle.net/10722/293539 |
ISSN | 2023 SCImago Journal Rankings: 1.016 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | BAI, X | - |
dc.contributor.author | YANG, B | - |
dc.contributor.author | Chen, H | - |
dc.contributor.author | Shen, J | - |
dc.contributor.author | Yang, D | - |
dc.date.accessioned | 2020-11-23T08:18:15Z | - |
dc.date.available | 2020-11-23T08:18:15Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Organic Chemistry Frontiers: an international journal of organic chemistry, 2020, v. 7 n. 8, p. 993-996 | - |
dc.identifier.issn | 2052-4110 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293539 | - |
dc.description.abstract | In order to understand the production and functions of HOCl in biological systems, a sensitive and selective detection method is urgently needed, especially for HOCl visualization in living cells and tissues. Herein we report a highly sensitive and selective rhodol-based fluorescent probe HKOCl-4 for HOCl detection. HKOCl-4r and HKOCl-4m, which were designed for better cellular uptake and mitochondria-targeting, respectively, have been successfully applied in detecting endogenous HOCl in macrophages. Furthermore, HOCl production in ischemic rat brain tissues has been visualized with HKOCl-4r in a middle cerebral artery occlusion (MCAO) model. These probes would serve as powerful imaging tools for delving into the roles of HOCl in health and disease. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/journals-books-databases/about-journals/organic-chemistry-frontiers/ | - |
dc.relation.ispartof | Organic Chemistry Frontiers: an international journal of organic chemistry | - |
dc.title | HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues | - |
dc.type | Article | - |
dc.identifier.email | Yang, D: yangdan@hku.hk | - |
dc.identifier.authority | Yang, D=rp00825 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/D0QO00081G | - |
dc.identifier.scopus | eid_2-s2.0-85083445513 | - |
dc.identifier.hkuros | 319200 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 993 | - |
dc.identifier.epage | 996 | - |
dc.identifier.isi | WOS:000526910600003 | - |
dc.publisher.place | United Kingdom | - |