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Article: Metalloproteomic approaches for matching metals to proteins: the power of inductively coupled plasma mass spectrometry (ICP-MS)

TitleMetalloproteomic approaches for matching metals to proteins: the power of inductively coupled plasma mass spectrometry (ICP-MS)
Authors
KeywordsICP-MS
Metalloproteomics
Molecular mechanisms
Issue Date2020
PublisherChemical Society of Japan. The Journal's web site is located at http://www.csj.jp/journals/chem-lett/index-e.html
Citation
Chemistry Letters, 2020, v. 49 n. 6, p. 697-704 How to Cite?
AbstractMetal/metalloid complexes have been commonly used in medicine as either therapeutic or diagnostic agents. Understanding the molecular mechanisms of action of metallodrugs is crucial for the development of more effective metallodrugs. Metalloproteomics serve as important tools for systematic analysis of metal-bound proteins within a cell or tissue type. Inductively coupled plasma mass spectrometry (ICP-MS), has been widely employed by metalloproteomic approaches. We summarize the latest progress of ICP-MS-based metalloproteomic approaches for the identification of putative protein targets of anticancer and antibacterial metallodrugs with the purpose of exploring their molecular mechanisms of action. The approach can also play a role in systems biology and precision medicine.
DescriptionLink to Open access
Persistent Identifierhttp://hdl.handle.net/10722/293536
ISSN
2023 Impact Factor: 1.4
2023 SCImago Journal Rankings: 0.423
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXU, X-
dc.contributor.authorWang, H-
dc.contributor.authorLi, H-
dc.contributor.authorSun, H-
dc.date.accessioned2020-11-23T08:18:13Z-
dc.date.available2020-11-23T08:18:13Z-
dc.date.issued2020-
dc.identifier.citationChemistry Letters, 2020, v. 49 n. 6, p. 697-704-
dc.identifier.issn0366-7022-
dc.identifier.urihttp://hdl.handle.net/10722/293536-
dc.descriptionLink to Open access-
dc.description.abstractMetal/metalloid complexes have been commonly used in medicine as either therapeutic or diagnostic agents. Understanding the molecular mechanisms of action of metallodrugs is crucial for the development of more effective metallodrugs. Metalloproteomics serve as important tools for systematic analysis of metal-bound proteins within a cell or tissue type. Inductively coupled plasma mass spectrometry (ICP-MS), has been widely employed by metalloproteomic approaches. We summarize the latest progress of ICP-MS-based metalloproteomic approaches for the identification of putative protein targets of anticancer and antibacterial metallodrugs with the purpose of exploring their molecular mechanisms of action. The approach can also play a role in systems biology and precision medicine.-
dc.languageeng-
dc.publisherChemical Society of Japan. The Journal's web site is located at http://www.csj.jp/journals/chem-lett/index-e.html-
dc.relation.ispartofChemistry Letters-
dc.rightsChemistry Letters. Copyright © Chemical Society of Japan.-
dc.rightsThe copyright belongs to the Chemical Society of Japan-
dc.subjectICP-MS-
dc.subjectMetalloproteomics-
dc.subjectMolecular mechanisms-
dc.titleMetalloproteomic approaches for matching metals to proteins: the power of inductively coupled plasma mass spectrometry (ICP-MS)-
dc.typeArticle-
dc.identifier.emailWang, H: wanghaib@hku.hk-
dc.identifier.emailLi, H: hylichem@hku.hk-
dc.identifier.emailSun, H: hsun@hku.hk-
dc.identifier.authoritySun, H=rp00777-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1246/cl.200155-
dc.identifier.scopuseid_2-s2.0-85087043627-
dc.identifier.hkuros318944-
dc.identifier.volume49-
dc.identifier.issue6-
dc.identifier.spage697-
dc.identifier.epage704-
dc.identifier.isiWOS:000539416400012-
dc.publisher.placeJapan-
dc.identifier.issnl0366-7022-

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