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Article: Proton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma

TitleProton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma
Authors
KeywordsNasopharyngeal carcinoma (NPC)
local recurrence
proton
heavy-ion
radiotherapy
Issue Date2020
PublisherAME Publishing Company. The Journal's web site is located at https://anpc.amegroups.com/
Citation
Annals of Nasopharynx Cancer, 2020, v. 4, p. article no. 4 How to Cite?
AbstractRadiotherapy is the major modality for treating advanced local recurrence of nasopharyngeal carcinoma (NPC). However, as the nearby critical neurological structures have already absorbed a dose close to their maximum tolerance in the primary treatment, even state-of-the-art intensity modulated radiotherapy (IMRT) cannot achieve a satisfactory dose distribution, and re-irradiation is often associated with serious, or even fatal, late complication, as well as substantial local failure. Proton/heavy-ion therapy, with their superior energy deposition characteristics and biological effectiveness, have the potential to overcome these obstacles. The use of proton/heavy-ion therapy to treat re-current NPC dates back to the last millennium when such facilities were extremely rare and dose delivery technique was in its infancy (mainly passive-scattered beams from very limited directions were available). Over the last two decades there have been substantial technological development in proton/heavy-ion therapy, the facilities have become much more widely available, with proton therapy being accepted as a suitable mean for re-irradiation setting in general. The advancement in diagnostic technology and systemic treatment have also contributed significantly to the effectiveness of such highly conformal radiotherapy modalities. Many have applied proton/heavy-ion therapy in the extremely challenging recurrent NPC situation, with various degrees of success. This article provides a brief review of the basic principle of proton/heavy-ion therapy, the issues unique to their usage, studies on their application in treating recurrent NPC and their possible future development.
Persistent Identifierhttp://hdl.handle.net/10722/293328
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLee, MCH-
dc.contributor.authorNg, WT-
dc.date.accessioned2020-11-23T08:15:10Z-
dc.date.available2020-11-23T08:15:10Z-
dc.date.issued2020-
dc.identifier.citationAnnals of Nasopharynx Cancer, 2020, v. 4, p. article no. 4-
dc.identifier.issn2616-4191-
dc.identifier.urihttp://hdl.handle.net/10722/293328-
dc.description.abstractRadiotherapy is the major modality for treating advanced local recurrence of nasopharyngeal carcinoma (NPC). However, as the nearby critical neurological structures have already absorbed a dose close to their maximum tolerance in the primary treatment, even state-of-the-art intensity modulated radiotherapy (IMRT) cannot achieve a satisfactory dose distribution, and re-irradiation is often associated with serious, or even fatal, late complication, as well as substantial local failure. Proton/heavy-ion therapy, with their superior energy deposition characteristics and biological effectiveness, have the potential to overcome these obstacles. The use of proton/heavy-ion therapy to treat re-current NPC dates back to the last millennium when such facilities were extremely rare and dose delivery technique was in its infancy (mainly passive-scattered beams from very limited directions were available). Over the last two decades there have been substantial technological development in proton/heavy-ion therapy, the facilities have become much more widely available, with proton therapy being accepted as a suitable mean for re-irradiation setting in general. The advancement in diagnostic technology and systemic treatment have also contributed significantly to the effectiveness of such highly conformal radiotherapy modalities. Many have applied proton/heavy-ion therapy in the extremely challenging recurrent NPC situation, with various degrees of success. This article provides a brief review of the basic principle of proton/heavy-ion therapy, the issues unique to their usage, studies on their application in treating recurrent NPC and their possible future development.-
dc.languageeng-
dc.publisherAME Publishing Company. The Journal's web site is located at https://anpc.amegroups.com/-
dc.relation.ispartofAnnals of Nasopharynx Cancer-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectNasopharyngeal carcinoma (NPC)-
dc.subjectlocal recurrence-
dc.subjectproton-
dc.subjectheavy-ion-
dc.subjectradiotherapy-
dc.titleProton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailNg, WT: ngwt1@hkucc.hku.hk-
dc.identifier.authorityNg, WT=rp02671-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.21037/anpc-20-7-
dc.identifier.hkuros319698-
dc.identifier.volume4-
dc.identifier.spagearticle no. 4-
dc.identifier.epagearticle no. 4-
dc.publisher.placeHong Kong-

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