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Article: Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

TitleDifferential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
Authors
Lau, SKPWONG, ACPLuk, HKHLi, KSMFUNG, JHE, ZCheng, FKKCHAN, TTYCHU, SAW YONG, KLLau, TCKFung, KSCWoo, PCY
Keywordsanimal
bat
genetics
human
Middle East respiratory syndrome coronavirus
Issue Date2020
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2020, v. 26 n. 12, p. 2961-2965 How to Cite?
DOI: http://dx.doi.org/10.3201/eid2612.202308
AbstractSevere acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Persistent Identifierhttp://hdl.handle.net/10722/293185
ISSN
1080-6040
2019 Impact Factor: 6.259
2015 SCImago Journal Rankings: 3.023
PubMed Central ID
PMC7706959

 

DC FieldValueLanguage
dc.contributor.authorLau, SKP-
dc.contributor.authorWONG, ACP-
dc.contributor.authorLuk, HKH-
dc.contributor.authorLi, KSM-
dc.contributor.authorFUNG, J-
dc.contributor.authorHE, Z-
dc.contributor.authorCheng, FKK-
dc.contributor.authorCHAN, TTY-
dc.contributor.authorCHU, S-
dc.contributor.authorAW YONG, KL-
dc.contributor.authorLau, TCK-
dc.contributor.authorFung, KSC-
dc.contributor.authorWoo, PCY-
dc.date.accessioned2020-11-23T08:13:03Z-
dc.date.available2020-11-23T08:13:03Z-
dc.date.issued2020-
dc.identifier.citationEmerging Infectious Diseases, 2020, v. 26 n. 12, p. 2961-2965-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/293185-
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectanimal-
dc.subjectbat-
dc.subjectgenetics-
dc.subjecthuman-
dc.subjectMiddle East respiratory syndrome coronavirus-
dc.titleDifferential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells-
dc.typeArticle-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailLuk, HKH: hkhluk@hku.hk-
dc.identifier.emailLi, KSM: kenn105@hkucc.hku.hk-
dc.identifier.emailCheng, FKK: florakkc@hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2612.202308-
dc.identifier.pmid32730733-
dc.identifier.pmcidPMC7706959-
dc.identifier.scopuseid_2-s2.0-85096508985-
dc.identifier.hkuros318832-
dc.identifier.volume26-
dc.identifier.issue12-
dc.identifier.spage2961-
dc.identifier.epage2965-
dc.publisher.placeUnited States-

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