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- Publisher Website: 10.1002/eji.1830200613
- Scopus: eid_2-s2.0-0025285665
- PMID: 2164478
- WOS: WOS:A1990DP82300012
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Article: Human suppressor T cell clones lack CD28
Title | Human suppressor T cell clones lack CD28 |
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Authors | |
Issue Date | 1990 |
Citation | European Journal of Immunology, 1990, v. 20, n. 6, p. 1281-1288 How to Cite? |
Abstract | Previously we showed that certain T cell lines and clones from a lepromatous leprosy patient displayed a dose‐dependent suppression of the proliferation of autologous T cells to Mycobacterium leprae (M. leprae) but not mitogen or an unrelatedantigen. The latter cells were also cloned and did not display this suppressive activity, were CD4+ and proliferated vigorously to M. leprae presented by autologous HLA‐DR molecules. We shall refer to these cells as T helper (Th) cells. Most of the suppressive T cell clones (Ts) were also CD4+ and also proliferated to M. leprae presented by HLA‐DR, but much less strongly than Th cells. In this study we report on our search for (a) the mechanism of this apparently antigen‐specific suppression by T cells, and (b) a possible phenotypic difference between Th and Ts clones. The two main conclusions are that Ts clones possess a lytic machinery, but that M. leprae‐specific suppression and cytotoxicity can be clearly dissociated, and that the only phenotypic difference between Th and Ts is the presence of the CD28 marker on Th and its absence on Ts clones. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim |
Persistent Identifier | http://hdl.handle.net/10722/292371 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Shu Guang | - |
dc.contributor.author | Ottenhoff, Tom H.M. | - |
dc.contributor.author | van den Elsen, Peter | - |
dc.contributor.author | Koning, Frits | - |
dc.contributor.author | Zhang, Li | - |
dc.contributor.author | Mak, Tak | - |
dc.contributor.author | De Vries, René R.P. | - |
dc.date.accessioned | 2020-11-17T14:56:19Z | - |
dc.date.available | 2020-11-17T14:56:19Z | - |
dc.date.issued | 1990 | - |
dc.identifier.citation | European Journal of Immunology, 1990, v. 20, n. 6, p. 1281-1288 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292371 | - |
dc.description.abstract | Previously we showed that certain T cell lines and clones from a lepromatous leprosy patient displayed a dose‐dependent suppression of the proliferation of autologous T cells to Mycobacterium leprae (M. leprae) but not mitogen or an unrelatedantigen. The latter cells were also cloned and did not display this suppressive activity, were CD4+ and proliferated vigorously to M. leprae presented by autologous HLA‐DR molecules. We shall refer to these cells as T helper (Th) cells. Most of the suppressive T cell clones (Ts) were also CD4+ and also proliferated to M. leprae presented by HLA‐DR, but much less strongly than Th cells. In this study we report on our search for (a) the mechanism of this apparently antigen‐specific suppression by T cells, and (b) a possible phenotypic difference between Th and Ts clones. The two main conclusions are that Ts clones possess a lytic machinery, but that M. leprae‐specific suppression and cytotoxicity can be clearly dissociated, and that the only phenotypic difference between Th and Ts is the presence of the CD28 marker on Th and its absence on Ts clones. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Immunology | - |
dc.title | Human suppressor T cell clones lack CD28 | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/eji.1830200613 | - |
dc.identifier.pmid | 2164478 | - |
dc.identifier.scopus | eid_2-s2.0-0025285665 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1281 | - |
dc.identifier.epage | 1288 | - |
dc.identifier.eissn | 1521-4141 | - |
dc.identifier.isi | WOS:A1990DP82300012 | - |
dc.identifier.issnl | 0014-2980 | - |