File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/cea.13739
- Scopus: eid_2-s2.0-85091605216
- PMID: 32949071
- WOS: WOS:000573183300001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Null association between serum 25‐hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non‐allergic rhinitis: A Mendelian randomization study
Title | Null association between serum 25‐hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non‐allergic rhinitis: A Mendelian randomization study |
---|---|
Authors | |
Keywords | 25‐hydroxyvitamin D allergic rhinitis allergic sensitization causation Mendelian randomization |
Issue Date | 2021 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2222 |
Citation | Clinical and Experimental Allergy, 2021, v. 51 n. 1, p. 78-86 How to Cite? |
Abstract | Background:
Previous observational studies have not found a conclusive association between serum 25‐hydroxyvitamin D (25(OH)D) levels and allergic rhinitis (AR) or allergic sensitization (AS).
Objective:
To investigate a causal association between 25(OH)D levels with risk of AR and AS, using a two‐sample Mendelian randomization (MR) approach.
Methods:
Seven single nucleotide polymorphisms (SNPs), previously shown to be associated with serum 25(OH)D levels, were identified as instrumental variables. The primary outcome was AR, and the secondary outcomes were AS and non‐allergic rhinitis (NAR). The genome‐wide association (GWA) summary statistics of the outcomes were obtained from two cohort studies (EAGLE Consortium and UK Biobank). An MR analysis with random‐effects inverse‐variance weighted method was performed as the primary analysis to estimate overall effect size (odds ratio [OR] and 95% confidence interval [CI]). Sensitivity analysis using weighted median method and MR‐Egger regression method was conducted. A subgroup analysis based on 25(OH)D synthesis‐related SNPs was further applied.
Results:
Serum 25(OH)D levels were not causally associated with risk of AR (OR: 0.960; 95% CI: 0.779‐1.184), AS (OR: 1.059; 95% CI: 0.686 to 1.634) or NAR (OR: 0.937; 95% CI: 0.588‐1.491). Subgroup analysis also showed null association between 25(OH)D synthesis‐related SNPs and the outcomes. Sensitivity analyses yielded similar results.
Conclusions and Clinical Relevance:
This MR study found no evidence supporting a causal association between serum 25(OH)D levels and risk of AR, AS and NAR in European‐ancestry population. This argues against the previous postulation that vitamin D supplementation is effective in prevention of allergic diseases. |
Persistent Identifier | http://hdl.handle.net/10722/290941 |
ISSN | 2023 Impact Factor: 6.3 2023 SCImago Journal Rankings: 1.290 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Feng, Q | - |
dc.contributor.author | Bønnelykke, K | - |
dc.contributor.author | Ek, WE | - |
dc.contributor.author | Chawes, BL | - |
dc.contributor.author | Yuan, S | - |
dc.contributor.author | Cheung, CL | - |
dc.contributor.author | Li, GHY | - |
dc.contributor.author | Leung, RYH | - |
dc.contributor.author | Cheung, BMY | - |
dc.date.accessioned | 2020-11-02T05:49:16Z | - |
dc.date.available | 2020-11-02T05:49:16Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Clinical and Experimental Allergy, 2021, v. 51 n. 1, p. 78-86 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | http://hdl.handle.net/10722/290941 | - |
dc.description.abstract | Background: Previous observational studies have not found a conclusive association between serum 25‐hydroxyvitamin D (25(OH)D) levels and allergic rhinitis (AR) or allergic sensitization (AS). Objective: To investigate a causal association between 25(OH)D levels with risk of AR and AS, using a two‐sample Mendelian randomization (MR) approach. Methods: Seven single nucleotide polymorphisms (SNPs), previously shown to be associated with serum 25(OH)D levels, were identified as instrumental variables. The primary outcome was AR, and the secondary outcomes were AS and non‐allergic rhinitis (NAR). The genome‐wide association (GWA) summary statistics of the outcomes were obtained from two cohort studies (EAGLE Consortium and UK Biobank). An MR analysis with random‐effects inverse‐variance weighted method was performed as the primary analysis to estimate overall effect size (odds ratio [OR] and 95% confidence interval [CI]). Sensitivity analysis using weighted median method and MR‐Egger regression method was conducted. A subgroup analysis based on 25(OH)D synthesis‐related SNPs was further applied. Results: Serum 25(OH)D levels were not causally associated with risk of AR (OR: 0.960; 95% CI: 0.779‐1.184), AS (OR: 1.059; 95% CI: 0.686 to 1.634) or NAR (OR: 0.937; 95% CI: 0.588‐1.491). Subgroup analysis also showed null association between 25(OH)D synthesis‐related SNPs and the outcomes. Sensitivity analyses yielded similar results. Conclusions and Clinical Relevance: This MR study found no evidence supporting a causal association between serum 25(OH)D levels and risk of AR, AS and NAR in European‐ancestry population. This argues against the previous postulation that vitamin D supplementation is effective in prevention of allergic diseases. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2222 | - |
dc.relation.ispartof | Clinical and Experimental Allergy | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | 25‐hydroxyvitamin D | - |
dc.subject | allergic rhinitis | - |
dc.subject | allergic sensitization | - |
dc.subject | causation | - |
dc.subject | Mendelian randomization | - |
dc.title | Null association between serum 25‐hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non‐allergic rhinitis: A Mendelian randomization study | - |
dc.type | Article | - |
dc.identifier.email | Cheung, CL: lung1212@hku.hk | - |
dc.identifier.email | Leung, RYH: yhleung@hku.hk | - |
dc.identifier.email | Cheung, BMY: mycheung@hkucc.hku.hk | - |
dc.identifier.authority | Cheung, CL=rp01749 | - |
dc.identifier.authority | Cheung, BMY=rp01321 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/cea.13739 | - |
dc.identifier.pmid | 32949071 | - |
dc.identifier.scopus | eid_2-s2.0-85091605216 | - |
dc.identifier.hkuros | 318447 | - |
dc.identifier.volume | 51 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 78 | - |
dc.identifier.epage | 86 | - |
dc.identifier.isi | WOS:000573183300001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0954-7894 | - |