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Article: Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

TitleStepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification
Authors
KeywordsNanocomposite
Magnesium ion
Microenvironment
3D scaffold
Bone tissue regeneration
Issue Date2021
PublisherKe Ai Publishing Communications Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X
Citation
Bioactive Materials, 2021, v. 6 n. 2, p. 503-519 How to Cite?
AbstractThe fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical, biological, or physical cues within a local tissue microenvironment. Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering. This study aims to investigate that the regulation of magnesium cationic (Mg2+) tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous ossification. It was discovered that moderate Mg2+ content niche (~4.11 mM) led to superior bone regeneration, while Mg2+-free and strong Mg2+ content (~16.44 mM) discouraged cell adhesion, proliferation and osteogenic differentiation, thereby bone formation was rarely found. When magnesium ions diffused into free Mg zone from concentrated zone in late time point, new bone formation on free Mg zone became significant through intramembranous ossification. This study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue regeneration. The knowledge of how a Mg2+ cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissue-repairing biomaterials.
Persistent Identifierhttp://hdl.handle.net/10722/290622
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorShen, J-
dc.contributor.authorCHEN, B-
dc.contributor.authorZhai, X-
dc.contributor.authorQiao, W-
dc.contributor.authorWu, S-
dc.contributor.authorLiu, X-
dc.contributor.authorZhao, Y-
dc.contributor.authorRuan, C-
dc.contributor.authorPan, H-
dc.contributor.authorChu, P-
dc.contributor.authorCheung, KMC-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2020-11-02T05:44:49Z-
dc.date.available2020-11-02T05:44:49Z-
dc.date.issued2021-
dc.identifier.citationBioactive Materials, 2021, v. 6 n. 2, p. 503-519-
dc.identifier.issn2452-199X-
dc.identifier.urihttp://hdl.handle.net/10722/290622-
dc.description.abstractThe fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical, biological, or physical cues within a local tissue microenvironment. Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering. This study aims to investigate that the regulation of magnesium cationic (Mg2+) tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous ossification. It was discovered that moderate Mg2+ content niche (~4.11 mM) led to superior bone regeneration, while Mg2+-free and strong Mg2+ content (~16.44 mM) discouraged cell adhesion, proliferation and osteogenic differentiation, thereby bone formation was rarely found. When magnesium ions diffused into free Mg zone from concentrated zone in late time point, new bone formation on free Mg zone became significant through intramembranous ossification. This study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue regeneration. The knowledge of how a Mg2+ cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissue-repairing biomaterials.-
dc.languageeng-
dc.publisherKe Ai Publishing Communications Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X-
dc.relation.ispartofBioactive Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectNanocomposite-
dc.subjectMagnesium ion-
dc.subjectMicroenvironment-
dc.subject3D scaffold-
dc.subjectBone tissue regeneration-
dc.titleStepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification-
dc.typeArticle-
dc.identifier.emailShen, J: jieshen@hku.hk-
dc.identifier.emailQiao, W: drqiao@hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.bioactmat.2020.08.025-
dc.identifier.pmid32995676-
dc.identifier.pmcidPMC7492774-
dc.identifier.scopuseid_2-s2.0-85090562707-
dc.identifier.hkuros318183-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.spage503-
dc.identifier.epage519-
dc.publisher.placeChina-

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