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- Publisher Website: 10.1364/OL.397733
- Scopus: eid_2-s2.0-85089128095
- PMID: 32735286
- WOS: WOS:000564876000052
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Article: Multiscale high-speed photoacoustic microscopy based on free-space light transmission and a MEMS scanning mirror
Title | Multiscale high-speed photoacoustic microscopy based on free-space light transmission and a MEMS scanning mirror |
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Authors | |
Keywords | Biological imaging Different resolutions High signal-to-noise ratio Lateral resolution MEMS scanning mirror |
Issue Date | 2020 |
Publisher | Optical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3 |
Citation | Optics Letters, 2020, v. 45 n. 15, p. 4312-4315 How to Cite? |
Abstract | The conventional photoacoustic microscopy (PAM) system allows trade-offs between lateral resolution and imaging depth, limiting its applications in biological imaging in vivo. Here we present an integrated optical-resolution (OR) and acoustic-resolution (AR) multiscale PAM based on free-space light transmission and fast microelectromechanical systems (MEMS) scanning. The lateral resolution for OR is 4.9 µm, and the lateral resolution for AR is 114.5 µm. The maximum imaging depth for OR is 0.7 mm, and the maximum imaging depth for AR is 4.1 mm. The imaging speed can reach 50 k Alines per second. The high signal-to-noise ratios and wavelength throughput are achieved by delivering light via free-space, and the high speed is achieved by a MEMS scanning mirror. The blood vasculature from superficial skin to the deep tissue of a mouse leg was imaged in vivo using two different resolutions to demonstrate the multiscale imaging capability. |
Persistent Identifier | http://hdl.handle.net/10722/290164 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.040 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, C | - |
dc.contributor.author | Zhao, H | - |
dc.contributor.author | Xu, S | - |
dc.contributor.author | Chen, N | - |
dc.contributor.author | Li, K | - |
dc.contributor.author | Jiang, X | - |
dc.contributor.author | Liu, L | - |
dc.contributor.author | Liu, Z | - |
dc.contributor.author | Wang, L | - |
dc.contributor.author | Wong, KKY | - |
dc.contributor.author | Zou, J | - |
dc.contributor.author | Liu, C | - |
dc.contributor.author | Song, L | - |
dc.date.accessioned | 2020-10-22T08:22:58Z | - |
dc.date.available | 2020-10-22T08:22:58Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Optics Letters, 2020, v. 45 n. 15, p. 4312-4315 | - |
dc.identifier.issn | 0146-9592 | - |
dc.identifier.uri | http://hdl.handle.net/10722/290164 | - |
dc.description.abstract | The conventional photoacoustic microscopy (PAM) system allows trade-offs between lateral resolution and imaging depth, limiting its applications in biological imaging in vivo. Here we present an integrated optical-resolution (OR) and acoustic-resolution (AR) multiscale PAM based on free-space light transmission and fast microelectromechanical systems (MEMS) scanning. The lateral resolution for OR is 4.9 µm, and the lateral resolution for AR is 114.5 µm. The maximum imaging depth for OR is 0.7 mm, and the maximum imaging depth for AR is 4.1 mm. The imaging speed can reach 50 k Alines per second. The high signal-to-noise ratios and wavelength throughput are achieved by delivering light via free-space, and the high speed is achieved by a MEMS scanning mirror. The blood vasculature from superficial skin to the deep tissue of a mouse leg was imaged in vivo using two different resolutions to demonstrate the multiscale imaging capability. | - |
dc.language | eng | - |
dc.publisher | Optical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3 | - |
dc.relation.ispartof | Optics Letters | - |
dc.rights | Optics Letters. Copyright © Optical Society of America. | - |
dc.rights | © XXXX [year] Optical Society of America]. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited. | - |
dc.subject | Biological imaging | - |
dc.subject | Different resolutions | - |
dc.subject | High signal-to-noise ratio | - |
dc.subject | Lateral resolution | - |
dc.subject | MEMS scanning mirror | - |
dc.title | Multiscale high-speed photoacoustic microscopy based on free-space light transmission and a MEMS scanning mirror | - |
dc.type | Article | - |
dc.identifier.email | Wong, KKY: kywong@eee.hku.hk | - |
dc.identifier.authority | Wong, KKY=rp00189 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1364/OL.397733 | - |
dc.identifier.pmid | 32735286 | - |
dc.identifier.scopus | eid_2-s2.0-85089128095 | - |
dc.identifier.hkuros | 316726 | - |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 15 | - |
dc.identifier.spage | 4312 | - |
dc.identifier.epage | 4315 | - |
dc.identifier.isi | WOS:000564876000052 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0146-9592 | - |