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Article: A surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus

TitleA surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus
Authors
KeywordsAntimicrobial
Copper
Immunoregulation
Macrophage
Phagocytosis
Issue Date2019
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2019, v. 208, p. 8-20 How to Cite?
AbstractMetal ions or nanoparticles are believed to be promising additives in developing antibacterial biomaterials, owing to possessing favorable bactericidal effects against antibiotic-resistant bacteria. However, the immunomodulatory antibacterial activity of metal ions has seldom been reported. Herein, a porous microstructure designed to trap methicillin-resistant Staphylococcus aureus (MRSA) is fabricated on polyetheretherketone biomaterial surface through sulfonation (SPEEK), following which copper (Cu) nanoparticles, which can kill the trapped MRSA, are immobilized on SPEEK surface using a customized magnetron sputtering technique. In vitro antibacterial and immunological experiments indicate that the Cu-incorporated SPEEK can exert a desirable bactericidal effect against MRSA through the combination of “trap killing” and “contact killing” actions; meanwhile, macrophages cultured on the Cu-incorporated SPEEK can be activated and polarized to a pro-inflammatory phenotype along with improved phagocytic ability on the MRSA. Further in vivo implant-associated infection models evidence the superior antibacterial activity of the Cu-incorporated SPEEK. These results demonstrate multimodal antibacterial actions of the Cu-incorporated SPEEK, which is capable of imposing direct antibacterial and indirect immunomodulatory antibacterial effects simultaneously, in order to prevent and cure MRSA infection. It is believed that this study may shed light on developing novel biomaterial implants that combine antibacterial and immunomodulatory functions.
Persistent Identifierhttp://hdl.handle.net/10722/289810
ISSN
2019 Impact Factor: 10.317
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLIU, W-
dc.contributor.authorLI, J-
dc.contributor.authorCHENG, M-
dc.contributor.authorWANG, Q-
dc.contributor.authorQIANG, Y-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCHU, PK-
dc.contributor.authorZHANG, X-
dc.date.accessioned2020-10-22T08:17:47Z-
dc.date.available2020-10-22T08:17:47Z-
dc.date.issued2019-
dc.identifier.citationBiomaterials, 2019, v. 208, p. 8-20-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10722/289810-
dc.description.abstractMetal ions or nanoparticles are believed to be promising additives in developing antibacterial biomaterials, owing to possessing favorable bactericidal effects against antibiotic-resistant bacteria. However, the immunomodulatory antibacterial activity of metal ions has seldom been reported. Herein, a porous microstructure designed to trap methicillin-resistant Staphylococcus aureus (MRSA) is fabricated on polyetheretherketone biomaterial surface through sulfonation (SPEEK), following which copper (Cu) nanoparticles, which can kill the trapped MRSA, are immobilized on SPEEK surface using a customized magnetron sputtering technique. In vitro antibacterial and immunological experiments indicate that the Cu-incorporated SPEEK can exert a desirable bactericidal effect against MRSA through the combination of “trap killing” and “contact killing” actions; meanwhile, macrophages cultured on the Cu-incorporated SPEEK can be activated and polarized to a pro-inflammatory phenotype along with improved phagocytic ability on the MRSA. Further in vivo implant-associated infection models evidence the superior antibacterial activity of the Cu-incorporated SPEEK. These results demonstrate multimodal antibacterial actions of the Cu-incorporated SPEEK, which is capable of imposing direct antibacterial and indirect immunomodulatory antibacterial effects simultaneously, in order to prevent and cure MRSA infection. It is believed that this study may shed light on developing novel biomaterial implants that combine antibacterial and immunomodulatory functions.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials-
dc.relation.ispartofBiomaterials-
dc.subjectAntimicrobial-
dc.subjectCopper-
dc.subjectImmunoregulation-
dc.subjectMacrophage-
dc.subjectPhagocytosis-
dc.titleA surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2019.04.008-
dc.identifier.pmid30986611-
dc.identifier.scopuseid_2-s2.0-85064524510-
dc.identifier.hkuros317568-
dc.identifier.volume208-
dc.identifier.spage8-
dc.identifier.epage20-
dc.identifier.isiWOS:000468249800002-
dc.publisher.placeNetherlands-
dc.identifier.issnl0142-9612-

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