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- Publisher Website: 10.1021/acsnano.0c01486
- Scopus: eid_2-s2.0-85089710511
- PMID: 32585104
- WOS: WOS:000557762800041
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Article: Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant
Title | Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant |
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Authors | |
Keywords | phototherapy immunotherapy antibacterial MRSA biofilm infection |
Issue Date | 2020 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html |
Citation | ACS Nano, 2020, v. 14 n. 7, p. 8157-8170 How to Cite? |
Abstract | Clinically, methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite (•ONOO–) was formed by the reaction between the released NO and superoxide (•O2–) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO– against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of Opn and Ocn genes and TNF-α. The MRSA biofilm was synergistically eradicated by •ONOO–, hyperthermia, and •O2– under NIR irradiation as well as the immunoreaction of the M1 polarization. The in vivo results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy. |
Persistent Identifier | http://hdl.handle.net/10722/289797 |
ISSN | 2023 Impact Factor: 15.8 2023 SCImago Journal Rankings: 4.593 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, Y | - |
dc.contributor.author | LIU, X | - |
dc.contributor.author | LI, B | - |
dc.contributor.author | ZHENG, Y | - |
dc.contributor.author | HAN, Y | - |
dc.contributor.author | CHEN, D | - |
dc.contributor.author | Yeung, KWK | - |
dc.contributor.author | CUI, Z | - |
dc.contributor.author | LIANG, Y | - |
dc.contributor.author | LI, Z | - |
dc.contributor.author | ZHU, S | - |
dc.contributor.author | WANG, X | - |
dc.contributor.author | WU, S | - |
dc.date.accessioned | 2020-10-22T08:17:37Z | - |
dc.date.available | 2020-10-22T08:17:37Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | ACS Nano, 2020, v. 14 n. 7, p. 8157-8170 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289797 | - |
dc.description.abstract | Clinically, methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite (•ONOO–) was formed by the reaction between the released NO and superoxide (•O2–) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO– against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of Opn and Ocn genes and TNF-α. The MRSA biofilm was synergistically eradicated by •ONOO–, hyperthermia, and •O2– under NIR irradiation as well as the immunoreaction of the M1 polarization. The in vivo results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html | - |
dc.relation.ispartof | ACS Nano | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.subject | phototherapy | - |
dc.subject | immunotherapy | - |
dc.subject | antibacterial | - |
dc.subject | MRSA | - |
dc.subject | biofilm infection | - |
dc.title | Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant | - |
dc.type | Article | - |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | - |
dc.identifier.authority | Yeung, KWK=rp00309 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acsnano.0c01486 | - |
dc.identifier.pmid | 32585104 | - |
dc.identifier.scopus | eid_2-s2.0-85089710511 | - |
dc.identifier.hkuros | 316841 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 8157 | - |
dc.identifier.epage | 8170 | - |
dc.identifier.isi | WOS:000557762800041 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1936-0851 | - |