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Article: Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant

TitleNear-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant
Authors
Keywordsphototherapy
immunotherapy
antibacterial
MRSA
biofilm infection
Issue Date2020
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html
Citation
ACS Nano, 2020, v. 14 n. 7, p. 8157-8170 How to Cite?
AbstractClinically, methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite (•ONOO–) was formed by the reaction between the released NO and superoxide (•O2–) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO– against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of Opn and Ocn genes and TNF-α. The MRSA biofilm was synergistically eradicated by •ONOO–, hyperthermia, and •O2– under NIR irradiation as well as the immunoreaction of the M1 polarization. The in vivo results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/289797
ISSN
2019 Impact Factor: 14.588
2015 SCImago Journal Rankings: 7.120

 

DC FieldValueLanguage
dc.contributor.authorLI, Y-
dc.contributor.authorLIU, X-
dc.contributor.authorLI, B-
dc.contributor.authorZHENG, Y-
dc.contributor.authorHAN, Y-
dc.contributor.authorCHEN, D-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCUI, Z-
dc.contributor.authorLIANG, Y-
dc.contributor.authorLI, Z-
dc.contributor.authorZHU, S-
dc.contributor.authorWANG, X-
dc.contributor.authorWU, S-
dc.date.accessioned2020-10-22T08:17:37Z-
dc.date.available2020-10-22T08:17:37Z-
dc.date.issued2020-
dc.identifier.citationACS Nano, 2020, v. 14 n. 7, p. 8157-8170-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/289797-
dc.description.abstractClinically, methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite (•ONOO–) was formed by the reaction between the released NO and superoxide (•O2–) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO– against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of Opn and Ocn genes and TNF-α. The MRSA biofilm was synergistically eradicated by •ONOO–, hyperthermia, and •O2– under NIR irradiation as well as the immunoreaction of the M1 polarization. The in vivo results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html-
dc.relation.ispartofACS Nano-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectphototherapy-
dc.subjectimmunotherapy-
dc.subjectantibacterial-
dc.subjectMRSA-
dc.subjectbiofilm infection-
dc.titleNear-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.0c01486-
dc.identifier.pmid32585104-
dc.identifier.scopuseid_2-s2.0-85089710511-
dc.identifier.hkuros316841-
dc.identifier.volume14-
dc.identifier.issue7-
dc.identifier.spage8157-
dc.identifier.epage8170-
dc.publisher.placeUnited States-

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