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- Publisher Website: 10.1007/s11095-020-02931-8
- Scopus: eid_2-s2.0-85092571945
- PMID: 33051728
- WOS: WOS:000577616700001
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Article: Multifunctional Microparticles Incorporating Gold Compound Inhibit Human Lung Cancer Xenograft
Title | Multifunctional Microparticles Incorporating Gold Compound Inhibit Human Lung Cancer Xenograft |
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Authors | |
Keywords | Gold porphyrin Interpenetrating network system drug formulation lung cancer drug delivery |
Issue Date | 2020 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741 |
Citation | Pharmaceutical Research, 2020, v. 37, p. article no. 220 How to Cite? |
Abstract | Purpose: Gold porphyrin (AuP) is a complex that has been shown to be potent against various tumors. A biocompatible interpenetrating network (IPN) system comprised of polyethyleneglycol diacrylate (PEGdA) and chemically-modified gelatin has been shown to be an effective implantable drug depot to deliver AuP locally. Here we designed IPN microparticles complexed with AuP to facilitate intravenous administration and to diminish systemic toxicity. Methods: We have synthesized and optimized an IPN microparticle formulation complexed with AuP. Tumor cell cytotoxicity, antitumor activity, and survival rate in lung cancer bearing nude mice were analyzed. Results: IPN microparticles maintained AuP bioactivity against lung cancer cells (NCI-H460). In vivo study showed no observable systemic toxicity in nude mice bearing NCI-H460 xenografts after intravenous injection of 6mg/kg AuP formulated with IPN microparticles. An anti-tumor activity level comparable to free AuP was maintained. Mice treated with 6mg/kg AuP in IPN microparticles showed 100% survival rate while the survival rate of mice treated with free AuP was much less. Furthermore, microparticle-formulated AuP significantly reduced the intratumoral microvasculature when compared with the control. Conclusion: AuP in IPN microparticles can reduce the systemic toxicity of AuP without compromising its antitumor activity. This work highlighted the potential application of AuP in IPN microparticles for anticancer chemotherapy. |
Persistent Identifier | http://hdl.handle.net/10722/289652 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.707 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, PY | - |
dc.contributor.author | Lok, CN | - |
dc.contributor.author | Che, CM | - |
dc.contributor.author | Kao, WJ | - |
dc.date.accessioned | 2020-10-22T08:15:34Z | - |
dc.date.available | 2020-10-22T08:15:34Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pharmaceutical Research, 2020, v. 37, p. article no. 220 | - |
dc.identifier.issn | 0724-8741 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289652 | - |
dc.description.abstract | Purpose: Gold porphyrin (AuP) is a complex that has been shown to be potent against various tumors. A biocompatible interpenetrating network (IPN) system comprised of polyethyleneglycol diacrylate (PEGdA) and chemically-modified gelatin has been shown to be an effective implantable drug depot to deliver AuP locally. Here we designed IPN microparticles complexed with AuP to facilitate intravenous administration and to diminish systemic toxicity. Methods: We have synthesized and optimized an IPN microparticle formulation complexed with AuP. Tumor cell cytotoxicity, antitumor activity, and survival rate in lung cancer bearing nude mice were analyzed. Results: IPN microparticles maintained AuP bioactivity against lung cancer cells (NCI-H460). In vivo study showed no observable systemic toxicity in nude mice bearing NCI-H460 xenografts after intravenous injection of 6mg/kg AuP formulated with IPN microparticles. An anti-tumor activity level comparable to free AuP was maintained. Mice treated with 6mg/kg AuP in IPN microparticles showed 100% survival rate while the survival rate of mice treated with free AuP was much less. Furthermore, microparticle-formulated AuP significantly reduced the intratumoral microvasculature when compared with the control. Conclusion: AuP in IPN microparticles can reduce the systemic toxicity of AuP without compromising its antitumor activity. This work highlighted the potential application of AuP in IPN microparticles for anticancer chemotherapy. | - |
dc.language | eng | - |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741 | - |
dc.relation.ispartof | Pharmaceutical Research | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.subject | Gold porphyrin | - |
dc.subject | Interpenetrating network system | - |
dc.subject | drug formulation | - |
dc.subject | lung cancer | - |
dc.subject | drug delivery | - |
dc.title | Multifunctional Microparticles Incorporating Gold Compound Inhibit Human Lung Cancer Xenograft | - |
dc.type | Article | - |
dc.identifier.email | Lee, PY: puiyanle@hku.hk | - |
dc.identifier.email | Lok, CN: cnlok@hkucc.hku.hk | - |
dc.identifier.email | Che, CM: chemhead@hku.hk | - |
dc.identifier.email | Kao, WJ: wjkao@hku.hk | - |
dc.identifier.authority | Lok, CN=rp00752 | - |
dc.identifier.authority | Che, CM=rp00670 | - |
dc.identifier.authority | Kao, WJ=rp02076 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s11095-020-02931-8 | - |
dc.identifier.pmid | 33051728 | - |
dc.identifier.scopus | eid_2-s2.0-85092571945 | - |
dc.identifier.hkuros | 316124 | - |
dc.identifier.volume | 37 | - |
dc.identifier.spage | article no. 220 | - |
dc.identifier.epage | article no. 220 | - |
dc.identifier.isi | WOS:000577616700001 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0724-8741 | - |