High-Resolution 3D Multi-shot Diffusion-Weighted Imaging with Pseudo-Random Sampling and Compressed Sensing

Abstract

3D multi-shot diffusion-weighted imaging (msDWI) with multi-slab acquisition can achieve high-resolution diffusion-tensor imaging (DTI), but additional correction is required to eliminate slab boundary artifact associated with multi-slab acquisition. A proposed 3D-MUSER technique can improve the feasible slab thickness by enabling 3D phase correction with a 3D single-shot navigator, thereby making single-slab 3D DTI feasible. However, the relatively long scantime can limit the applications of 3D DTI in neuroscience research, despite high spatial resolution attainable. In this study, we proposed a potential strategy to develop a 3D DTI technique capable of high scan acceleration.