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Article: Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis

TitleMaternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis
Authors
Keywordsgestation
child development
offspring
pregnancy
thyroid
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at https://academic.oup.com/jcem
Citation
The Journal of Clinical Endocrinology & Metabolism, 2020, v. 105 n. 12, p. 3821-3841 How to Cite?
AbstractContext: Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring. Objective: To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring. Data Sources: PubMed, EMBASE, and Cochrane Library. Study Selections: Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children. Data Extraction: Reviewers extracted data on study characteristics and results independently. Data Synthesis: Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies. Results: We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring. Conclusion: Routine measurement and timely treatment on thyroid function should be considered for pregnant women.
Persistent Identifierhttp://hdl.handle.net/10722/289379
ISSN
2019 Impact Factor: 5.399
2015 SCImago Journal Rankings: 2.940

 

DC FieldValueLanguage
dc.contributor.authorGe, GM-
dc.contributor.authorLeung, MTY-
dc.contributor.authorMan, KKC-
dc.contributor.authorLeung, WC-
dc.contributor.authorIp, P-
dc.contributor.authorLi, GHY-
dc.contributor.authorWong, ICK-
dc.contributor.authorKung, AWC-
dc.contributor.authorCheung, CL-
dc.date.accessioned2020-10-22T08:11:48Z-
dc.date.available2020-10-22T08:11:48Z-
dc.date.issued2020-
dc.identifier.citationThe Journal of Clinical Endocrinology & Metabolism, 2020, v. 105 n. 12, p. 3821-3841-
dc.identifier.issn0021-972X-
dc.identifier.urihttp://hdl.handle.net/10722/289379-
dc.description.abstractContext: Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring. Objective: To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring. Data Sources: PubMed, EMBASE, and Cochrane Library. Study Selections: Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children. Data Extraction: Reviewers extracted data on study characteristics and results independently. Data Synthesis: Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies. Results: We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring. Conclusion: Routine measurement and timely treatment on thyroid function should be considered for pregnant women.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at https://academic.oup.com/jcem-
dc.relation.ispartofThe Journal of Clinical Endocrinology & Metabolism-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectgestation-
dc.subjectchild development-
dc.subjectoffspring-
dc.subjectpregnancy-
dc.subjectthyroid-
dc.titleMaternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis-
dc.typeArticle-
dc.identifier.emailLeung, MTY: mleungty@hku.hk-
dc.identifier.emailMan, KKC: mkckth@hku.hk-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailLi, GHY: gloriali@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailKung, AWC: awckung@hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.authorityIp, P=rp01337-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityKung, AWC=rp00368-
dc.identifier.authorityCheung, CL=rp01749-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/clinem/dgaa555-
dc.identifier.pmid32810262-
dc.identifier.scopuseid_2-s2.0-85092332251-
dc.identifier.hkuros316026-
dc.identifier.volume105-
dc.identifier.issue12-
dc.identifier.spage3821-
dc.identifier.epage3841-
dc.publisher.placeUnited States-

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