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Article: Zn2+-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs

TitleZn2+-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs
Authors
KeywordsHumic acid
MOF
Photothermal
Controlled release
Antibacterial
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/colsurfb
Citation
Colloids and Surfaces B: Biointerfaces, 2020, v. 188, p. article no. 110781 How to Cite?
AbstractBacterial infection is seriously threatening human health all over the world, especially with the emergence of increasing drug-fast bacteria. It is urgent to develop a drug-free strategy to kill bacteria rapidly and efficiently. In this work, humic acid (HuA) encapsulated zeolitic imidazole framework-8 (ZIF-8) (HuA@ZIF-8) nanocomposites are synthesized by the in-situ growth of ZIF-8 on the surface of polyvinylpyrrolidone (PVP)-modified HuA. The synthesized nanocomposites possesses good photothermal effects, i.e., the temperature increased to 59.4 °C under the particle concentration of 1000 μg/mL with 10 min NIR irradiation. In addition, NIR irradiation can also control the release of Zn2+ from the composites. The good photothermal effects originate from HuA that can effectively absorb NIR light. The controlled release of Zn2+ is ascribed to the induced-dissociation of ZIF-8 under NIR light irradiation. The synergistic action of photothermal therapy and release of zinc ions contributes to the excellent antibacterial efficiency of HuA@ZIF-8 within a short time, i.e. 99.59 % and 99.37 % against Staphylococcus aureus and Escherichia coli with 20 min NIR irradiation, respectively. This work provides a promising strategy to develop a light-responsive platform with good biodegradability and low cost for rapid and effective sterilization.
Persistent Identifierhttp://hdl.handle.net/10722/289135
ISSN
2019 Impact Factor: 4.389
2015 SCImago Journal Rankings: 1.105

 

DC FieldValueLanguage
dc.contributor.authorLIU, Z-
dc.contributor.authorTAN, L-
dc.contributor.authorLIU, X-
dc.contributor.authorLIANG, Y-
dc.contributor.authorZHENG, Y-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCUI, Z-
dc.contributor.authorZHU, S-
dc.contributor.authorLI, Z-
dc.contributor.authorWU, S-
dc.date.accessioned2020-10-22T08:08:18Z-
dc.date.available2020-10-22T08:08:18Z-
dc.date.issued2020-
dc.identifier.citationColloids and Surfaces B: Biointerfaces, 2020, v. 188, p. article no. 110781-
dc.identifier.issn0927-7765-
dc.identifier.urihttp://hdl.handle.net/10722/289135-
dc.description.abstractBacterial infection is seriously threatening human health all over the world, especially with the emergence of increasing drug-fast bacteria. It is urgent to develop a drug-free strategy to kill bacteria rapidly and efficiently. In this work, humic acid (HuA) encapsulated zeolitic imidazole framework-8 (ZIF-8) (HuA@ZIF-8) nanocomposites are synthesized by the in-situ growth of ZIF-8 on the surface of polyvinylpyrrolidone (PVP)-modified HuA. The synthesized nanocomposites possesses good photothermal effects, i.e., the temperature increased to 59.4 °C under the particle concentration of 1000 μg/mL with 10 min NIR irradiation. In addition, NIR irradiation can also control the release of Zn2+ from the composites. The good photothermal effects originate from HuA that can effectively absorb NIR light. The controlled release of Zn2+ is ascribed to the induced-dissociation of ZIF-8 under NIR light irradiation. The synergistic action of photothermal therapy and release of zinc ions contributes to the excellent antibacterial efficiency of HuA@ZIF-8 within a short time, i.e. 99.59 % and 99.37 % against Staphylococcus aureus and Escherichia coli with 20 min NIR irradiation, respectively. This work provides a promising strategy to develop a light-responsive platform with good biodegradability and low cost for rapid and effective sterilization.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/colsurfb-
dc.relation.ispartofColloids and Surfaces B: Biointerfaces-
dc.subjectHumic acid-
dc.subjectMOF-
dc.subjectPhotothermal-
dc.subjectControlled release-
dc.subjectAntibacterial-
dc.titleZn2+-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.colsurfb.2020.110781-
dc.identifier.pmid31935632-
dc.identifier.scopuseid_2-s2.0-85077652024-
dc.identifier.hkuros317559-
dc.identifier.volume188-
dc.identifier.spagearticle no. 110781-
dc.identifier.epagearticle no. 110781-
dc.publisher.placeNetherlands-

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