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- Publisher Website: 10.1016/j.psychres.2015.08.018
- Scopus: eid_2-s2.0-84941258751
- PMID: 26296754
- WOS: WOS:000362141300006
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Article: Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia
Title | Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia |
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Authors | |
Keywords | Angiotensin Converting Enzyme (ACE) Interleukin-17 (IL-17) Cytokine Biomarker Schizophrenia Inflammatory response Inflammation |
Issue Date | 2015 |
Citation | Psychiatry Research, 2015, v. 229, n. 3, p. 702-707 How to Cite? |
Abstract | © 2015 Elsevier Ireland Ltd. Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-α), and interferon (IFN-γ). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-γ levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-γ, in patients with SCZ. |
Persistent Identifier | http://hdl.handle.net/10722/288670 |
ISSN | 2021 Impact Factor: 11.225 2020 SCImago Journal Rankings: 1.224 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gadelha, Ary | - |
dc.contributor.author | Yonamine, Camila M. | - |
dc.contributor.author | Nering, Marcela | - |
dc.contributor.author | Rizzo, Lucas Bortolotto | - |
dc.contributor.author | Noto, Cristiano | - |
dc.contributor.author | Cogo-Moreira, Hugo | - |
dc.contributor.author | Teixeira, Antônio Lúcio | - |
dc.contributor.author | Bressan, Rodrigo | - |
dc.contributor.author | Maes, Michael | - |
dc.contributor.author | Brietzke, Elisa | - |
dc.contributor.author | Hayashi, Mirian A.F. | - |
dc.date.accessioned | 2020-10-12T08:05:34Z | - |
dc.date.available | 2020-10-12T08:05:34Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Psychiatry Research, 2015, v. 229, n. 3, p. 702-707 | - |
dc.identifier.issn | 0165-1781 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288670 | - |
dc.description.abstract | © 2015 Elsevier Ireland Ltd. Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-α), and interferon (IFN-γ). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-γ levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-γ, in patients with SCZ. | - |
dc.language | eng | - |
dc.relation.ispartof | Psychiatry Research | - |
dc.subject | Angiotensin Converting Enzyme (ACE) | - |
dc.subject | Interleukin-17 (IL-17) | - |
dc.subject | Cytokine | - |
dc.subject | Biomarker | - |
dc.subject | Schizophrenia | - |
dc.subject | Inflammatory response | - |
dc.subject | Inflammation | - |
dc.title | Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.psychres.2015.08.018 | - |
dc.identifier.pmid | 26296754 | - |
dc.identifier.scopus | eid_2-s2.0-84941258751 | - |
dc.identifier.volume | 229 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 702 | - |
dc.identifier.epage | 707 | - |
dc.identifier.eissn | 1872-7123 | - |
dc.identifier.isi | WOS:000362141300006 | - |
dc.identifier.issnl | 0165-1781 | - |