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Article: The AO trauma CPP bone infection registry: Epidemiology and outcomes of Staphylococcus aureus bone infection

TitleThe AO trauma CPP bone infection registry: Epidemiology and outcomes of Staphylococcus aureus bone infection
Authors
Keywordsbone infection registry
fracture‐related infection
MRSA
implant‐related infection
Staphylococcus aureus
Issue Date2021
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1554-527X
Citation
Journal of Orthopaedic Research, 2021, v. 39 n. 1, p. 136-146 How to Cite?
AbstractBone infection represents a serious complication of orthopedic surgery and Staphylococcus aureus is the most common pathogen. To improve the understanding of host‐pathogen interaction, we developed a biospecimen registry (AO Trauma CPP Bone Infection Registry) to collect clinical data, bacterial isolates, and serum from patients with S. aureus bone infection. A prospective multinational registry with a 12‐month follow‐up was created to include adult patients (18 years or older) with culture‐confirmed S. aureus infection in long bones after fracture fixation or arthroplasty. Baseline patient attributes and details on infections and treatments were recorded. Blood and serum samples were obtained at baseline, 6, and 12 months. Patient‐reported outcomes were collected at 1, 6, and 12 months. Clinical outcomes were recorded. Two hundred and ninety‐two patients with fracture‐related infection (n = 157, 53.8%), prosthetic joint infection (n = 86, 29.5%), and osteomyelitis (n = 49, 16.8%) were enrolled. Methicillin‐resistant S. aureus was detected in 82 patients (28.4%), with the highest proportion found among patients from North American sites (n = 39, 48.8%) and the lowest from Central European sites (n = 18, 12.2%). Patient outcomes improved at 6 and 12 months in comparison to baseline. The SF‐36 physical component summary mean (95% confidence interval) score, however, did not reach 50 at 12 months. The cure rate at the end of the study period was 62.1%. Although patients improved with treatment, less than two‐thirds were cured in 1 year. At 12‐month follow‐up, patient‐reported outcome scores were worse for patients with methicillin‐resistant S. aureus infections.
Persistent Identifierhttp://hdl.handle.net/10722/287684
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.886
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMorgenstern, M-
dc.contributor.authorErichsen, C-
dc.contributor.authorMilitz, M-
dc.contributor.authorXie, Z-
dc.contributor.authorPeng, J-
dc.contributor.authorStannard, J-
dc.contributor.authorMetsemakers, WJ-
dc.contributor.authorSchaefer, D-
dc.contributor.authorAlt, V-
dc.contributor.authorSøballe, K-
dc.contributor.authorNerlich, M-
dc.contributor.authorBuckley, RE-
dc.contributor.authorBlauth, M-
dc.contributor.authorSuk, M-
dc.contributor.authorLeung, F-
dc.contributor.authorBarla, JD-
dc.contributor.authorYukata, K-
dc.contributor.authorQing, B-
dc.contributor.authorKates, SL-
dc.date.accessioned2020-10-05T12:01:43Z-
dc.date.available2020-10-05T12:01:43Z-
dc.date.issued2021-
dc.identifier.citationJournal of Orthopaedic Research, 2021, v. 39 n. 1, p. 136-146-
dc.identifier.issn0736-0266-
dc.identifier.urihttp://hdl.handle.net/10722/287684-
dc.description.abstractBone infection represents a serious complication of orthopedic surgery and Staphylococcus aureus is the most common pathogen. To improve the understanding of host‐pathogen interaction, we developed a biospecimen registry (AO Trauma CPP Bone Infection Registry) to collect clinical data, bacterial isolates, and serum from patients with S. aureus bone infection. A prospective multinational registry with a 12‐month follow‐up was created to include adult patients (18 years or older) with culture‐confirmed S. aureus infection in long bones after fracture fixation or arthroplasty. Baseline patient attributes and details on infections and treatments were recorded. Blood and serum samples were obtained at baseline, 6, and 12 months. Patient‐reported outcomes were collected at 1, 6, and 12 months. Clinical outcomes were recorded. Two hundred and ninety‐two patients with fracture‐related infection (n = 157, 53.8%), prosthetic joint infection (n = 86, 29.5%), and osteomyelitis (n = 49, 16.8%) were enrolled. Methicillin‐resistant S. aureus was detected in 82 patients (28.4%), with the highest proportion found among patients from North American sites (n = 39, 48.8%) and the lowest from Central European sites (n = 18, 12.2%). Patient outcomes improved at 6 and 12 months in comparison to baseline. The SF‐36 physical component summary mean (95% confidence interval) score, however, did not reach 50 at 12 months. The cure rate at the end of the study period was 62.1%. Although patients improved with treatment, less than two‐thirds were cured in 1 year. At 12‐month follow‐up, patient‐reported outcome scores were worse for patients with methicillin‐resistant S. aureus infections.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1554-527X-
dc.relation.ispartofJournal of Orthopaedic Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbone infection registry-
dc.subjectfracture‐related infection-
dc.subjectMRSA-
dc.subjectimplant‐related infection-
dc.subjectStaphylococcus aureus-
dc.titleThe AO trauma CPP bone infection registry: Epidemiology and outcomes of Staphylococcus aureus bone infection-
dc.typeArticle-
dc.identifier.emailLeung, F: klleunga@hkucc.hku.hk-
dc.identifier.authorityLeung, F=rp00297-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/jor.24804-
dc.identifier.pmid32720352-
dc.identifier.pmcidPMC7749080-
dc.identifier.scopuseid_2-s2.0-85088593488-
dc.identifier.hkuros314879-
dc.identifier.volume39-
dc.identifier.issue1-
dc.identifier.spage136-
dc.identifier.epage146-
dc.identifier.eissn1554-527X-
dc.identifier.isiWOS:000552640600001-
dc.publisher.placeUnited States-
dc.identifier.issnl0736-0266-

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