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Article: Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

TitleClinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Authors
KeywordsCOVID-19
H1N1
neonatal
pregnancy
vertical transmission
Issue Date2020
PublisherOxford University Press (OUP): Policy C. The Journal's web site is located at http://ofid.oxfordjournals.org/
Citation
Open Forum Infectious Diseases, 2020, v. 7 n. 7, p. article no. ofaa283 How to Cite?
AbstractBackground: Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China. Methods: We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1. Results: Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs 6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion; 5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8–9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1. Conclusions: Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. No evidence indicated that pregnant women may have fetal infection through vertical transmission of COVID-19. Pregnant patients with H1N1 had more serious condition than those with COVID-19.
Persistent Identifierhttp://hdl.handle.net/10722/287672
ISSN
2019 Impact Factor: 3.656
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, S-
dc.contributor.authorShao, F-
dc.contributor.authorBao, B-
dc.contributor.authorMa, X-
dc.contributor.authorXu, Z-
dc.contributor.authorYou, J-
dc.contributor.authorZhao, P-
dc.contributor.authorLiu, Y-
dc.contributor.authorNg, M-
dc.contributor.authorCui, H-
dc.contributor.authorYu, C-
dc.contributor.authorZhang, Q-
dc.contributor.authorLi, D-
dc.contributor.authorTang, Z-
dc.contributor.authorSun, P-
dc.date.accessioned2020-10-05T12:01:32Z-
dc.date.available2020-10-05T12:01:32Z-
dc.date.issued2020-
dc.identifier.citationOpen Forum Infectious Diseases, 2020, v. 7 n. 7, p. article no. ofaa283-
dc.identifier.issn2328-8957-
dc.identifier.urihttp://hdl.handle.net/10722/287672-
dc.description.abstractBackground: Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China. Methods: We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1. Results: Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs 6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion; 5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8–9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1. Conclusions: Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. No evidence indicated that pregnant women may have fetal infection through vertical transmission of COVID-19. Pregnant patients with H1N1 had more serious condition than those with COVID-19.-
dc.languageeng-
dc.publisherOxford University Press (OUP): Policy C. The Journal's web site is located at http://ofid.oxfordjournals.org/-
dc.relation.ispartofOpen Forum Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectH1N1-
dc.subjectneonatal-
dc.subjectpregnancy-
dc.subjectvertical transmission-
dc.titleClinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China-
dc.typeArticle-
dc.identifier.emailNg, M: michael.ng@hku.hk-
dc.identifier.authorityNg, M=rp02578-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/ofid/ofaa283-
dc.identifier.pmid32743014-
dc.identifier.pmcidPMC7384380-
dc.identifier.scopuseid_2-s2.0-85090755829-
dc.identifier.hkuros315743-
dc.identifier.volume7-
dc.identifier.issue7-
dc.identifier.spagearticle no. ofaa283-
dc.identifier.epagearticle no. ofaa283-
dc.identifier.isiWOS:000577171200050-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2328-8957-

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