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Article: Anti-cancer activities of S-allylmercaptocysteine from aged garlic

TitleAnti-cancer activities of S-allylmercaptocysteine from aged garlic
Authors
KeywordsAged garlic
S-allylmercaptocysteine
Cancer
Molecular pathway
Reactive oxygen species
Issue Date2019
PublisherElsevier Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/18755364
Citation
Chinese Journal of Natural Medicines, 2019, v. 17 n. 1, p. 43-49 How to Cite?
AbstractWhile most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine (SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management.
Persistent Identifierhttp://hdl.handle.net/10722/287590
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLV, Y-
dc.contributor.authorSo, KF-
dc.contributor.authorWong, NK-
dc.contributor.authorXiao, J-
dc.date.accessioned2020-10-05T12:00:18Z-
dc.date.available2020-10-05T12:00:18Z-
dc.date.issued2019-
dc.identifier.citationChinese Journal of Natural Medicines, 2019, v. 17 n. 1, p. 43-49-
dc.identifier.issn1875-5364-
dc.identifier.urihttp://hdl.handle.net/10722/287590-
dc.description.abstractWhile most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine (SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/18755364-
dc.relation.ispartofChinese Journal of Natural Medicines-
dc.subjectAged garlic-
dc.subjectS-allylmercaptocysteine-
dc.subjectCancer-
dc.subjectMolecular pathway-
dc.subjectReactive oxygen species-
dc.titleAnti-cancer activities of S-allylmercaptocysteine from aged garlic-
dc.typeArticle-
dc.identifier.emailXiao, J: jiaxiao@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1875-5364(19)30008-1-
dc.identifier.pmid30704623-
dc.identifier.scopuseid_2-s2.0-85060528085-
dc.identifier.hkuros315702-
dc.identifier.volume17-
dc.identifier.issue1-
dc.identifier.spage43-
dc.identifier.epage49-
dc.publisher.placeUnited Kingdom-

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