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Article: Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

TitleElectroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity
Authors
KeywordsBrain Derived Neurotrophic Factor
Electroconvulsive Therapy
Schizophrenia
Issue Date2020
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/
Citation
Neural Plasticity, 2020, v. 2020, p. 8818328:1-8818328:13 How to Cite?
AbstractPoststroke cognitive impairment (PSCI) is a severe sequela of stroke. There are no effective therapeutic options for it. In this study, we evaluated whether electroacupuncture (EA) on the trigeminal nerve-innervated acupoints could alleviate PSCI and identified the mechanisms in an animal model. The male Sprague-Dawley rat middle cerebral artery occlusion (MCAO) model was used in our study. EA was conducted on the two scalp acupoints, EX-HN3 (Yintang) and GV20 (Baihui), innervated by the trigeminal nerve, for 14 sessions, daily. Morris water maze and novel object recognition were used to evaluate the animal’s cognitive performance. Neuroprotection and synaptic plasticity biomarkers were analyzed in brain tissues. Ischemia-reperfusion (I/R) injury significantly impaired spatial and cognition memory, while EA obviously reversed cognitive deterioration to the control level in the two cognitive paradigms. Moreover, EA reversed the I/R injury-induced decrease of brain-derived neurotrophic factor, tyrosine kinase B, N-methyl-D-aspartic acid receptor 1, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, γ-aminobutyric acid type A receptors, Ca2+/calmodulin-dependent protein kinase II, neuronal nuclei, and postsynaptic density protein 95 expression in the prefrontal cortex and hippocampus. These results suggest that EA on the trigeminal nerve-innervated acupoints is an effective therapy for PSCI, in association with mediating neuroprotection and synaptic plasticity in related brain regions in the MCAO rat model.
Persistent Identifierhttp://hdl.handle.net/10722/287325
ISSN
2019 Impact Factor: 3.093
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorZHENG, Y-
dc.contributor.authorQIN, Z-
dc.contributor.authorTsoi, B-
dc.contributor.authorShen, J-
dc.contributor.authorZhang, ZJ-
dc.date.accessioned2020-09-22T02:59:19Z-
dc.date.available2020-09-22T02:59:19Z-
dc.date.issued2020-
dc.identifier.citationNeural Plasticity, 2020, v. 2020, p. 8818328:1-8818328:13-
dc.identifier.issn2090-5904-
dc.identifier.urihttp://hdl.handle.net/10722/287325-
dc.description.abstractPoststroke cognitive impairment (PSCI) is a severe sequela of stroke. There are no effective therapeutic options for it. In this study, we evaluated whether electroacupuncture (EA) on the trigeminal nerve-innervated acupoints could alleviate PSCI and identified the mechanisms in an animal model. The male Sprague-Dawley rat middle cerebral artery occlusion (MCAO) model was used in our study. EA was conducted on the two scalp acupoints, EX-HN3 (Yintang) and GV20 (Baihui), innervated by the trigeminal nerve, for 14 sessions, daily. Morris water maze and novel object recognition were used to evaluate the animal’s cognitive performance. Neuroprotection and synaptic plasticity biomarkers were analyzed in brain tissues. Ischemia-reperfusion (I/R) injury significantly impaired spatial and cognition memory, while EA obviously reversed cognitive deterioration to the control level in the two cognitive paradigms. Moreover, EA reversed the I/R injury-induced decrease of brain-derived neurotrophic factor, tyrosine kinase B, N-methyl-D-aspartic acid receptor 1, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, γ-aminobutyric acid type A receptors, Ca2+/calmodulin-dependent protein kinase II, neuronal nuclei, and postsynaptic density protein 95 expression in the prefrontal cortex and hippocampus. These results suggest that EA on the trigeminal nerve-innervated acupoints is an effective therapy for PSCI, in association with mediating neuroprotection and synaptic plasticity in related brain regions in the MCAO rat model.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/-
dc.relation.ispartofNeural Plasticity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBrain Derived Neurotrophic Factor-
dc.subjectElectroconvulsive Therapy-
dc.subjectSchizophrenia-
dc.titleElectroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity-
dc.typeArticle-
dc.identifier.emailTsoi, B: amytsoi@hku.hk-
dc.identifier.emailShen, J: shenjg@hku.hk-
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hk-
dc.identifier.authorityShen, J=rp00487-
dc.identifier.authorityZhang, ZJ=rp01297-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2020/8818328-
dc.identifier.pmid32963517-
dc.identifier.pmcidPMC7492933-
dc.identifier.scopuseid_2-s2.0-85091563017-
dc.identifier.hkuros314428-
dc.identifier.volume2020-
dc.identifier.spage8818328:1-
dc.identifier.epage8818328:13-
dc.publisher.placeUnited States-

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