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Article: The impact of cigarette smoking in predicting stroke using CHADS2 and CHA2DS2-VASc schemas
Title | The impact of cigarette smoking in predicting stroke using CHADS2 and CHA2DS2-VASc schemas |
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Authors | |
Keywords | Ischemic stroke Cigarette smoking Risk prediction CHADS2 CHA2DS2-VASc |
Issue Date | 2021 |
Publisher | Springer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=249 |
Citation | Neurological Sciences, 2021, v. 42 n. 1, p. 159-166 How to Cite? |
Abstract | Objective:
To determine the impact of smoking status in the prediction of stroke using CHADS2 and CHA2DS2-VASc schemes.
Methods:
Five hundred twenty-eight consecutive patients with arrhythmic symptoms and without any documented arrhythmia from Queen Mary Hospital, Hong Kong, were followed up to determine the incidence of ischemic stroke, new-onset atrial fibrillation (AF), or all-cause mortality. Smoking status was classified into nonsmokers and smokers. The pairwise comparisons of C-statistics for outcomes were performed.
Results:
During a median follow-up period of 6.2 years, 65 (12.3%) individuals developed ischemic stroke. Smokers experienced higher annual incidence of stroke, a new-onset AF, and all-cause death compare to nonsmokers, with corresponding hazard ratio (HR) of stroke, AF, and all-cause death being 2.51 (95% confidence intervals, CI 1.36als, CIse death bein 1.15a3.24), and 1.95 (95% CI 1.161.95 (95% CIath being 2.51 (95% confidence corr2 and CHA2DS2-VASc for stroke were 0.60 (95% CI 0.51 for stp = 0.09) and 0.59 (95% CI 0.50 (95%, p = 0.15) respectively, whereas the C-statistics of CHADS2 and CHA2DS2-VASc were 0.66 (95% CI 0.61 were 0p = 0.005), 0.75 (95% CI 0.7 CI 0.7p < 0.0001), respectively among nonsmokers. After incorporating smoking, both the CHADS2-smoking and CHA2DS2-VASc-smoking achieved better C-statistics for new-onset ischemic stroke prediction superior to baseline score systems in male groups.
Conclusion:
Cigarette smoking status has impact on stroke stratification using CHADS2 and CHA2DS2-VASc scheme. The discrimination of the CHADS2 and CHA2DS2-VASc scheme for stroke can be significantly improved if smoking status is additionally considered. |
Persistent Identifier | http://hdl.handle.net/10722/287155 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.738 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zuo, ML | - |
dc.contributor.author | Li, CM | - |
dc.contributor.author | Deng, Y | - |
dc.contributor.author | Bhattacharyya, S | - |
dc.contributor.author | Shuai, P | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Siu, CW | - |
dc.contributor.author | Yin, LX | - |
dc.date.accessioned | 2020-09-22T02:56:37Z | - |
dc.date.available | 2020-09-22T02:56:37Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Neurological Sciences, 2021, v. 42 n. 1, p. 159-166 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | http://hdl.handle.net/10722/287155 | - |
dc.description.abstract | Objective: To determine the impact of smoking status in the prediction of stroke using CHADS2 and CHA2DS2-VASc schemes. Methods: Five hundred twenty-eight consecutive patients with arrhythmic symptoms and without any documented arrhythmia from Queen Mary Hospital, Hong Kong, were followed up to determine the incidence of ischemic stroke, new-onset atrial fibrillation (AF), or all-cause mortality. Smoking status was classified into nonsmokers and smokers. The pairwise comparisons of C-statistics for outcomes were performed. Results: During a median follow-up period of 6.2 years, 65 (12.3%) individuals developed ischemic stroke. Smokers experienced higher annual incidence of stroke, a new-onset AF, and all-cause death compare to nonsmokers, with corresponding hazard ratio (HR) of stroke, AF, and all-cause death being 2.51 (95% confidence intervals, CI 1.36als, CIse death bein 1.15a3.24), and 1.95 (95% CI 1.161.95 (95% CIath being 2.51 (95% confidence corr2 and CHA2DS2-VASc for stroke were 0.60 (95% CI 0.51 for stp = 0.09) and 0.59 (95% CI 0.50 (95%, p = 0.15) respectively, whereas the C-statistics of CHADS2 and CHA2DS2-VASc were 0.66 (95% CI 0.61 were 0p = 0.005), 0.75 (95% CI 0.7 CI 0.7p < 0.0001), respectively among nonsmokers. After incorporating smoking, both the CHADS2-smoking and CHA2DS2-VASc-smoking achieved better C-statistics for new-onset ischemic stroke prediction superior to baseline score systems in male groups. Conclusion: Cigarette smoking status has impact on stroke stratification using CHADS2 and CHA2DS2-VASc scheme. The discrimination of the CHADS2 and CHA2DS2-VASc scheme for stroke can be significantly improved if smoking status is additionally considered. | - |
dc.language | eng | - |
dc.publisher | Springer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=249 | - |
dc.relation.ispartof | Neurological Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Ischemic stroke | - |
dc.subject | Cigarette smoking | - |
dc.subject | Risk prediction | - |
dc.subject | CHADS2 | - |
dc.subject | CHA2DS2-VASc | - |
dc.title | The impact of cigarette smoking in predicting stroke using CHADS2 and CHA2DS2-VASc schemas | - |
dc.type | Article | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Siu, CW: cwdsiu@hkucc.hku.hk | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Siu, CW=rp00534 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1007/s10072-020-04455-w | - |
dc.identifier.pmid | 32572660 | - |
dc.identifier.pmcid | PMC7819918 | - |
dc.identifier.scopus | eid_2-s2.0-85086779338 | - |
dc.identifier.hkuros | 314395 | - |
dc.identifier.volume | 42 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 159 | - |
dc.identifier.epage | 166 | - |
dc.identifier.isi | WOS:000542096300001 | - |
dc.publisher.place | Italy | - |
dc.identifier.issnl | 1590-1874 | - |