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Article: Advanced Reconfigurable Scaffolds Fabricated by 4D Printing for Treating Critical-size Bone Defects of Irregular Shapes

TitleAdvanced Reconfigurable Scaffolds Fabricated by 4D Printing for Treating Critical-size Bone Defects of Irregular Shapes
Authors
KeywordsTissue Engineering
Polycaprolactone
Selective Laser Sintering
Issue Date2020
PublisherInstitute of Physics Publishing Ltd. The Journal's web site is located at http://www.iop.org/EJ/journal/bf
Citation
Biofabrication, 2020, v. 12 n. 4, p. article no. 045025 How to Cite?
AbstractWhile scaffold-based tissue engineering has been widely used to treat bone critical-size defects, challenges such as implantation of scaffolds in defects with irregular shapes and implantation of scaffolds through minimally invasive surgery remain in the tissue engineering field. Customized bioactive bone tissue engineering scaffolds with reconfigurable capability for both easy scaffold implantation and perfect shape fitting in irregularly shaped bone defects are therefore needed. Herein, applying 4D printing, photothermal-responsive shape memory bone tissue engineering scaffolds are constructed by incorporating black phosphorus nanosheets and osteogenic peptide into β-tricalcium phosphate/poly(lactic acid-co-trimethylene carbonate) (TCP/P(DLLA-TMC)) nanocomposite scaffolds. When near-infrared irradiation is applied to customized scaffolds on-demand, scaffold temperature rapidly increases to 45 °C, enabling scaffold shape reconfiguration for easy scaffold implantation and precise fitting in irregular bone defects. Once the implantation is finished, scaffold temperature rapidly decreases to 37 °C and scaffolds display mechanical properties comparable to those of human cancellous bone. The improved osteogenesis in bone defect sites is then initiated through pulsed peptide release from scaffolds. Compact integration of reconfigurable scaffolds in rat cranial bone defects and improved new bone formation are demonstrated through micro-computed tomography and histochemical analyses. This study shows a facile method to clinically treat bone defects of irregular shapes.
Persistent Identifierhttp://hdl.handle.net/10722/286227
ISSN
2019 Impact Factor: 8.213
2015 SCImago Journal Rankings: 1.505
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, C-
dc.contributor.authorYue, H-
dc.contributor.authorLiu, J-
dc.contributor.authorZhao, Q-
dc.contributor.authorHe, Z-
dc.contributor.authorLi, K-
dc.contributor.authorLu, B-
dc.contributor.authorHuang, W-
dc.contributor.authorWei, Y-
dc.contributor.authorTang, Y-
dc.contributor.authorWang, M-
dc.date.accessioned2020-08-31T07:00:57Z-
dc.date.available2020-08-31T07:00:57Z-
dc.date.issued2020-
dc.identifier.citationBiofabrication, 2020, v. 12 n. 4, p. article no. 045025-
dc.identifier.issn1758-5082-
dc.identifier.urihttp://hdl.handle.net/10722/286227-
dc.description.abstractWhile scaffold-based tissue engineering has been widely used to treat bone critical-size defects, challenges such as implantation of scaffolds in defects with irregular shapes and implantation of scaffolds through minimally invasive surgery remain in the tissue engineering field. Customized bioactive bone tissue engineering scaffolds with reconfigurable capability for both easy scaffold implantation and perfect shape fitting in irregularly shaped bone defects are therefore needed. Herein, applying 4D printing, photothermal-responsive shape memory bone tissue engineering scaffolds are constructed by incorporating black phosphorus nanosheets and osteogenic peptide into β-tricalcium phosphate/poly(lactic acid-co-trimethylene carbonate) (TCP/P(DLLA-TMC)) nanocomposite scaffolds. When near-infrared irradiation is applied to customized scaffolds on-demand, scaffold temperature rapidly increases to 45 °C, enabling scaffold shape reconfiguration for easy scaffold implantation and precise fitting in irregular bone defects. Once the implantation is finished, scaffold temperature rapidly decreases to 37 °C and scaffolds display mechanical properties comparable to those of human cancellous bone. The improved osteogenesis in bone defect sites is then initiated through pulsed peptide release from scaffolds. Compact integration of reconfigurable scaffolds in rat cranial bone defects and improved new bone formation are demonstrated through micro-computed tomography and histochemical analyses. This study shows a facile method to clinically treat bone defects of irregular shapes.-
dc.languageeng-
dc.publisherInstitute of Physics Publishing Ltd. The Journal's web site is located at http://www.iop.org/EJ/journal/bf-
dc.relation.ispartofBiofabrication-
dc.rightsBiofabrication. Copyright © Institute of Physics Publishing Ltd.-
dc.rightsThis is an author-created, un-copyedited version of an article published in [insert name of journal]. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/[insert DOI].-
dc.subjectTissue Engineering-
dc.subjectPolycaprolactone-
dc.subjectSelective Laser Sintering-
dc.titleAdvanced Reconfigurable Scaffolds Fabricated by 4D Printing for Treating Critical-size Bone Defects of Irregular Shapes-
dc.typeArticle-
dc.identifier.emailYue, H: hbyue@hku.hk-
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1088/1758-5090/abab5b-
dc.identifier.pmid32736373-
dc.identifier.scopuseid_2-s2.0-85089708995-
dc.identifier.hkuros313376-
dc.identifier.volume12-
dc.identifier.issue4-
dc.identifier.spagearticle no. 045025-
dc.identifier.epagearticle no. 045025-
dc.identifier.isiWOS:000563227400001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1758-5082-

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