File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1097/MOT.0000000000000689
- Scopus: eid_2-s2.0-85071269830
- PMID: 31408016
- WOS: WOS:000491293600020
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Is living donor liver transplantation justified in high model for end-stage liver disease candidates (35+)?
Title | Is living donor liver transplantation justified in high model for end-stage liver disease candidates (35+)? |
---|---|
Authors | |
Keywords | high model for end-stage liver disease living donor liver transplantation surgical outcomes |
Issue Date | 2019 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.co-transplantation.com |
Citation | Current Opinion in Organ Transplantation, 2019, v. 24 n. 5, p. 637-643 How to Cite? |
Abstract | Purpose of review:
Application of living donor liver transplantation (LDLT) in model for end-stage liver disease (MELD) 35+ patients has been regarded with skepticism. There is concern that a partial graft may not achieve favourable outcomes, and that a healthy donor is risked for a transplant which might turn out to be futile.
Recent findings:
In practice, LDLT improves access to liver graft and allows timely transplantation. Long-term results from high-volume centres revealed that outcomes of LDLT in these patients have not been jeopardized by limited graft volumes. With unimpeded vascular outflow, a partial graft could provide sufficient function to overcome the stress of transplant operation. However, LDLT is a complex operation with immense technical demand. A steep learning curve is encountered before optimal outcomes could be produced. Meanwhile, donor safety remains the paramount concern. Donor should not be evaluated for futile candidates. MELD 35+ patients with refractory sepsis or cardiac event are unlikely to benefit from liver transplantation. Borderline donors, in terms of donor safety or graft quality, should not be accepted. As in recipient operation, accumulation of experience is crucial to reduce donor mortality and morbidity.
Summary:
LDLT is justified for MELD 35+ in high-volume centres with vast experience. Satisfactory recipient outcomes can be produced with minimal donor morbidity. |
Persistent Identifier | http://hdl.handle.net/10722/285319 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.744 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Au, KP | - |
dc.contributor.author | Chan, ACY | - |
dc.date.accessioned | 2020-08-18T03:52:22Z | - |
dc.date.available | 2020-08-18T03:52:22Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Current Opinion in Organ Transplantation, 2019, v. 24 n. 5, p. 637-643 | - |
dc.identifier.issn | 1087-2418 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285319 | - |
dc.description.abstract | Purpose of review: Application of living donor liver transplantation (LDLT) in model for end-stage liver disease (MELD) 35+ patients has been regarded with skepticism. There is concern that a partial graft may not achieve favourable outcomes, and that a healthy donor is risked for a transplant which might turn out to be futile. Recent findings: In practice, LDLT improves access to liver graft and allows timely transplantation. Long-term results from high-volume centres revealed that outcomes of LDLT in these patients have not been jeopardized by limited graft volumes. With unimpeded vascular outflow, a partial graft could provide sufficient function to overcome the stress of transplant operation. However, LDLT is a complex operation with immense technical demand. A steep learning curve is encountered before optimal outcomes could be produced. Meanwhile, donor safety remains the paramount concern. Donor should not be evaluated for futile candidates. MELD 35+ patients with refractory sepsis or cardiac event are unlikely to benefit from liver transplantation. Borderline donors, in terms of donor safety or graft quality, should not be accepted. As in recipient operation, accumulation of experience is crucial to reduce donor mortality and morbidity. Summary: LDLT is justified for MELD 35+ in high-volume centres with vast experience. Satisfactory recipient outcomes can be produced with minimal donor morbidity. | - |
dc.language | eng | - |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.co-transplantation.com | - |
dc.relation.ispartof | Current Opinion in Organ Transplantation | - |
dc.rights | This is a non-final version of an article published in final form in (provide complete journal citation) | - |
dc.subject | high model for end-stage liver disease | - |
dc.subject | living donor liver transplantation | - |
dc.subject | surgical outcomes | - |
dc.title | Is living donor liver transplantation justified in high model for end-stage liver disease candidates (35+)? | - |
dc.type | Article | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/MOT.0000000000000689 | - |
dc.identifier.pmid | 31408016 | - |
dc.identifier.scopus | eid_2-s2.0-85071269830 | - |
dc.identifier.hkuros | 312951 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 637 | - |
dc.identifier.epage | 643 | - |
dc.identifier.isi | WOS:000491293600020 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1087-2418 | - |