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Article: Evaluation of pancreatic lesions with endoscopic ultrasound and fine needle aspiration

TitleEvaluation of pancreatic lesions with endoscopic ultrasound and fine needle aspiration
Authors
KeywordsHepatobiliary
flexible endoscopy
interventional endoscopy
Issue Date2020
PublisherSage Publications, Inc. The Journal's web site is located at http://sri.sagepub.com
Citation
Surgical Innovation, 2020, Epub 2020-05-30 How to Cite?
AbstractBackground. Endoscopic ultrasound (EUS) and fine-needle aspiration (FNA) are commonly used for assessing pancreatic lesions. This study aimed to evaluate the diagnostic yield and accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a single tertiary institution. Methods. Consecutive patients who underwent EUS-FNA of the pancreas at Queen Mary Hospital, Hong Kong, from January 2015 to March 2016 were retrospectively reviewed. Endoscopic findings and FNA results were analysed. For patients who subsequently underwent surgical resection of pancreatic lesion, EUS-FNA diagnoses were compared to histopathological findings of surgical specimens to determine its diagnostic accuracy. Results. One hundred twelve EUS-FNA were performed in 99 patients within the study time period and were included for analysis. Sixty-six (66.7%) pancreatic lesions were solid in nature and 33 (33.3%) were cystic. The overall diagnostic yield of EUS-FNA was 70.5% (n = 79). On multivariate analysis, more passes of needle were associated with a higher diagnostic yield (odds ratio = 2.000, P = .049). 57.1% (n = 64) of EUS-FNA results had an impact on management. Sixteen patients with diagnostic EUS-FNA subsequently underwent surgery for resection of the pancreatic lesion. Upon correlation to the histopathological findings of surgical specimens, there were 12 true-positive, 2 true-negative, 0 false-positive, and 2 false-negative cases. Sensitivity was 85.7%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 50%. The diagnostic accuracy of EUS-FNA was 87.5%. Conclusion. EUS-FNA is accurate and reliable for diagnosing pancreatic lesions.
Persistent Identifierhttp://hdl.handle.net/10722/285316
ISSN
2019 Impact Factor: 1.458
2015 SCImago Journal Rankings: 0.534

 

DC FieldValueLanguage
dc.contributor.authorLuk, Y-
dc.contributor.authorShe, WH-
dc.contributor.authorChow, FCL-
dc.contributor.authorMa, KW-
dc.contributor.authorTsang, SHY-
dc.contributor.authorDai, WC-
dc.contributor.authorCheung, TT-
dc.contributor.authorLo, CM-
dc.date.accessioned2020-08-18T03:52:21Z-
dc.date.available2020-08-18T03:52:21Z-
dc.date.issued2020-
dc.identifier.citationSurgical Innovation, 2020, Epub 2020-05-30-
dc.identifier.issn1553-3506-
dc.identifier.urihttp://hdl.handle.net/10722/285316-
dc.description.abstractBackground. Endoscopic ultrasound (EUS) and fine-needle aspiration (FNA) are commonly used for assessing pancreatic lesions. This study aimed to evaluate the diagnostic yield and accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a single tertiary institution. Methods. Consecutive patients who underwent EUS-FNA of the pancreas at Queen Mary Hospital, Hong Kong, from January 2015 to March 2016 were retrospectively reviewed. Endoscopic findings and FNA results were analysed. For patients who subsequently underwent surgical resection of pancreatic lesion, EUS-FNA diagnoses were compared to histopathological findings of surgical specimens to determine its diagnostic accuracy. Results. One hundred twelve EUS-FNA were performed in 99 patients within the study time period and were included for analysis. Sixty-six (66.7%) pancreatic lesions were solid in nature and 33 (33.3%) were cystic. The overall diagnostic yield of EUS-FNA was 70.5% (n = 79). On multivariate analysis, more passes of needle were associated with a higher diagnostic yield (odds ratio = 2.000, P = .049). 57.1% (n = 64) of EUS-FNA results had an impact on management. Sixteen patients with diagnostic EUS-FNA subsequently underwent surgery for resection of the pancreatic lesion. Upon correlation to the histopathological findings of surgical specimens, there were 12 true-positive, 2 true-negative, 0 false-positive, and 2 false-negative cases. Sensitivity was 85.7%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 50%. The diagnostic accuracy of EUS-FNA was 87.5%. Conclusion. EUS-FNA is accurate and reliable for diagnosing pancreatic lesions.-
dc.languageeng-
dc.publisherSage Publications, Inc. The Journal's web site is located at http://sri.sagepub.com-
dc.relation.ispartofSurgical Innovation-
dc.rightsSurgical Innovation. Copyright © Sage Publications, Inc.-
dc.subjectHepatobiliary-
dc.subjectflexible endoscopy-
dc.subjectinterventional endoscopy-
dc.titleEvaluation of pancreatic lesions with endoscopic ultrasound and fine needle aspiration-
dc.typeArticle-
dc.identifier.emailShe, WH: brianshe@hku.hk-
dc.identifier.emailDai, WC: daiwc@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/1553350620925321-
dc.identifier.pmid32476606-
dc.identifier.scopuseid_2-s2.0-85085624583-
dc.identifier.hkuros312942-
dc.identifier.volumeEpub 2020-05-30-
dc.publisher.placeUnited States-

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