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Conference Paper: Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus
Title | Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus |
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Authors | |
Keywords | Cardiovascular Disease in Women |
Issue Date | 2019 |
Publisher | Oxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/ |
Citation | European Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology, Paris, France, 31 August – 4 September 2019. In European Heart Journal, 2019, v. 40 n. Suppl. 1, abstract no. P3461 How to Cite? |
Abstract | Background: Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodeling and diastolic dysfunction in patients with type 2 diabetes (T2DM).
Purpose: The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodeling and diastolic dysfunction in patients with T2DM. Further the prognostic value of diastolic function in women and men was also evaluated.
Methods: A total of 386 patients with T2DM (mean age 61±11 years; women, 48.2%) was recruited. Detailed echocardiography was performed and LV geometry, systolic and diastolic function were measured at baseline and follow-up. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization or myocardial infarction. Multivariable cox-regression adjusted for age, hypertension, LVEF and HbA1c was used to assess the association between sex-specific diastolic function and the development of a MACE.
Results: Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 26 patients developed a MACE (4 cardiovascular death, 14 hospitalization for heart failure, 8 myocardial infarction) during follow-up. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women (hazard ratio 6.35, 95% confidence interval 1.18–34.19, P<0.05) but not men (hazard ratio 1.85, 95% confidence interval 0.58–5.92, P=0.30).
Conclusions: LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men. |
Description | Poster Session 4: Cardiovascular Disease in Women - no. P3461 |
Persistent Identifier | http://hdl.handle.net/10722/285108 |
ISSN | 2023 Impact Factor: 37.6 2023 SCImago Journal Rankings: 4.091 |
DC Field | Value | Language |
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dc.contributor.author | Wu, M | - |
dc.contributor.author | Chen, Y | - |
dc.contributor.author | Yu, Y | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Yiu, KH | - |
dc.date.accessioned | 2020-08-07T09:06:52Z | - |
dc.date.available | 2020-08-07T09:06:52Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | European Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology, Paris, France, 31 August – 4 September 2019. In European Heart Journal, 2019, v. 40 n. Suppl. 1, abstract no. P3461 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | http://hdl.handle.net/10722/285108 | - |
dc.description | Poster Session 4: Cardiovascular Disease in Women - no. P3461 | - |
dc.description.abstract | Background: Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodeling and diastolic dysfunction in patients with type 2 diabetes (T2DM). Purpose: The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodeling and diastolic dysfunction in patients with T2DM. Further the prognostic value of diastolic function in women and men was also evaluated. Methods: A total of 386 patients with T2DM (mean age 61±11 years; women, 48.2%) was recruited. Detailed echocardiography was performed and LV geometry, systolic and diastolic function were measured at baseline and follow-up. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization or myocardial infarction. Multivariable cox-regression adjusted for age, hypertension, LVEF and HbA1c was used to assess the association between sex-specific diastolic function and the development of a MACE. Results: Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 26 patients developed a MACE (4 cardiovascular death, 14 hospitalization for heart failure, 8 myocardial infarction) during follow-up. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women (hazard ratio 6.35, 95% confidence interval 1.18–34.19, P<0.05) but not men (hazard ratio 1.85, 95% confidence interval 0.58–5.92, P=0.30). Conclusions: LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/ | - |
dc.relation.ispartof | European Heart Journal | - |
dc.relation.ispartof | European Society of Cardiology (ESC) Congress 2019 & World Congress of Cardiology | - |
dc.subject | Cardiovascular Disease in Women | - |
dc.title | Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.identifier.doi | 10.1093/eurheartj/ehz745.0334 | - |
dc.identifier.hkuros | 311771 | - |
dc.identifier.volume | 40 | - |
dc.identifier.issue | Suppl. 1 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0195-668X | - |