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Article: CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T

TitleCEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T
Authors
KeywordsCEST MRI
hydrogel
liposome
glioblastoma
Issue Date2020
PublisherIvyspring International Publisher. The Journal's web site is located at http://www.thno.org/
Citation
Theranostics, 2020, v. 10 n. 5, p. 2215-2228 How to Cite?
AbstractAdjuvant treatment using local drug delivery is applied in treating glioblastoma multiforme (GBM) after tumor resection. However, there are no non-invasive imaging techniques available for tracking the compositional changes of hydrogel-based drug treatment. Methods: We developed Chemical Exchange Saturation Transfer Magnetic Resonance Imaging (CEST MRI) detectable and injectable liposomal hydrogel to monitor these events in vivo at 3T clinical field. Mechanical attributes of these hydrogels and their in vitro and in vivo CEST imaging properties were systematically studied. Results: The MRI detectable hydrogels were capable of generating multiparametric readouts for monitoring specific components of the hydrogel matrix simultaneously and independently. Herein, we report, for the first time, CEST contrast at -3.4 ppm provides an estimated number of liposomes and CEST contrast at 5 ppm provides an estimated amount of encapsulated drug. CEST contrast decreased by 1.57% at 5 ppm, while the contrast at -3.4 ppm remained constant over 3 d in vivo, demonstrating different release kinetics of these components from the hydrogel matrix. Furthermore, histology analysis confirmed that the CEST contrast at -3.4 ppm was associated with liposome concentrations. Conclusion: This multiparametric CEST imaging of individual compositional changes in liposomal hydrogels, formulated with clinical-grade materials at 3T and described in this study, has the potential to facilitate the refinement of adjuvant treatment for GBM.
Persistent Identifierhttp://hdl.handle.net/10722/284250
ISSN
2019 Impact Factor: 8.579
2015 SCImago Journal Rankings: 2.702
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWu, EX-
dc.contributor.authorHan, X-
dc.contributor.authorHuang, J-
dc.contributor.authorTo, AKW-
dc.contributor.authorLai, JHC-
dc.contributor.authorXiao, P-
dc.contributor.authorXu, J-
dc.contributor.authorChan, KWY-
dc.date.accessioned2020-07-20T05:57:15Z-
dc.date.available2020-07-20T05:57:15Z-
dc.date.issued2020-
dc.identifier.citationTheranostics, 2020, v. 10 n. 5, p. 2215-2228-
dc.identifier.issn1838-7640-
dc.identifier.urihttp://hdl.handle.net/10722/284250-
dc.description.abstractAdjuvant treatment using local drug delivery is applied in treating glioblastoma multiforme (GBM) after tumor resection. However, there are no non-invasive imaging techniques available for tracking the compositional changes of hydrogel-based drug treatment. Methods: We developed Chemical Exchange Saturation Transfer Magnetic Resonance Imaging (CEST MRI) detectable and injectable liposomal hydrogel to monitor these events in vivo at 3T clinical field. Mechanical attributes of these hydrogels and their in vitro and in vivo CEST imaging properties were systematically studied. Results: The MRI detectable hydrogels were capable of generating multiparametric readouts for monitoring specific components of the hydrogel matrix simultaneously and independently. Herein, we report, for the first time, CEST contrast at -3.4 ppm provides an estimated number of liposomes and CEST contrast at 5 ppm provides an estimated amount of encapsulated drug. CEST contrast decreased by 1.57% at 5 ppm, while the contrast at -3.4 ppm remained constant over 3 d in vivo, demonstrating different release kinetics of these components from the hydrogel matrix. Furthermore, histology analysis confirmed that the CEST contrast at -3.4 ppm was associated with liposome concentrations. Conclusion: This multiparametric CEST imaging of individual compositional changes in liposomal hydrogels, formulated with clinical-grade materials at 3T and described in this study, has the potential to facilitate the refinement of adjuvant treatment for GBM.-
dc.languageeng-
dc.publisherIvyspring International Publisher. The Journal's web site is located at http://www.thno.org/-
dc.relation.ispartofTheranostics-
dc.rightsTheranostics. Copyright © Ivyspring International Publisher.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCEST MRI-
dc.subjecthydrogel-
dc.subjectliposome-
dc.subjectglioblastoma-
dc.titleCEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T-
dc.typeArticle-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7150/thno.40146-
dc.identifier.pmid32089739-
dc.identifier.pmcidPMC7019148-
dc.identifier.scopuseid_2-s2.0-85078276539-
dc.identifier.hkuros311198-
dc.identifier.volume10-
dc.identifier.issue5-
dc.identifier.spage2215-
dc.identifier.epage2228-
dc.publisher.placeAustralia-

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