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Article: Epidemiological and Clinical Characteristics of Human Hepegivirus 1 Infection in Patients With Hepatitis C
Title | Epidemiological and Clinical Characteristics of Human Hepegivirus 1 Infection in Patients With Hepatitis C |
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Authors | |
Keywords | hepatitis C virus human hepegivirus 1 hepatitis |
Issue Date | 2019 |
Publisher | Oxford University Press (OUP): Policy C. The Journal's web site is located at http://ofid.oxfordjournals.org/ |
Citation | Open Forum Infectious Diseases, 2019, v. 6 n. 8, p. article no. ofz329 How to Cite? |
Abstract | Background:
Transmission of human hepegivirus 1 (HHpgV-1), a novel human pegivirus, is closely associated with hepatitis C virus (HCV). The impact of HHpgV-1 viremia on HCV infection is unknown. This study aimed to (a) evaluate the impact of HHpgV-1 viremia on HCV viral load and liver injury and (b) elucidate the clinical and molecular epidemiology of HHpgV-1 infection.
Methods:
Individuals with HHpgV-1 viremia (cases) were identified by screening plasma from 655 HCV-infected adults. HHpgV-1 isolates were sequenced for phylogenetic analysis, and viral load was quantified. Cases were age- and sex-matched to HCV-infected individuals without HHpgV-1 viremia (controls) in a 1:3 ratio. A retrospective case–control analysis was performed to identify differences in HCV viral load and parameters of liver injury.
Results:
Among HCV-infected adults, 16/655 (2.4%) had HHpgV-1 viremia. Risk groups for HHpgV-1 infection included intravenous drug users, blood product recipients, tattoo recipients, and men who have sex with men. Viral sequences clustered into 2 distinct HHpgV-1 genogroups. Cases had a higher mean HCV viral load than controls, with difference between means of 0.58 log10 IU/mL (P = .009). Cases were more likely to have an HCV viral load >5 log10 IU/mL (P = .028). Multiple regression demonstrated the impact of HHpgV-1 viral load and infection status on HCV viral load. HHpgV-1 infection was not associated with higher liver function tests, fibrosis scores, or imaging abnormalities.
Conclusions:
HHpgV-1 viremia is associated with a higher HCV viral load in co-infected patients. HHpgV-1 infection does not affect progression of HCV-related liver disease. |
Persistent Identifier | http://hdl.handle.net/10722/284102 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.360 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sridhar, S | - |
dc.contributor.author | Yip, CCY | - |
dc.contributor.author | Chew, NFS | - |
dc.contributor.author | Wu, S | - |
dc.contributor.author | Leung, KH | - |
dc.contributor.author | Chan, JFW | - |
dc.contributor.author | Cheng, VCC | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2020-07-20T05:56:06Z | - |
dc.date.available | 2020-07-20T05:56:06Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Open Forum Infectious Diseases, 2019, v. 6 n. 8, p. article no. ofz329 | - |
dc.identifier.issn | 2328-8957 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284102 | - |
dc.description.abstract | Background: Transmission of human hepegivirus 1 (HHpgV-1), a novel human pegivirus, is closely associated with hepatitis C virus (HCV). The impact of HHpgV-1 viremia on HCV infection is unknown. This study aimed to (a) evaluate the impact of HHpgV-1 viremia on HCV viral load and liver injury and (b) elucidate the clinical and molecular epidemiology of HHpgV-1 infection. Methods: Individuals with HHpgV-1 viremia (cases) were identified by screening plasma from 655 HCV-infected adults. HHpgV-1 isolates were sequenced for phylogenetic analysis, and viral load was quantified. Cases were age- and sex-matched to HCV-infected individuals without HHpgV-1 viremia (controls) in a 1:3 ratio. A retrospective case–control analysis was performed to identify differences in HCV viral load and parameters of liver injury. Results: Among HCV-infected adults, 16/655 (2.4%) had HHpgV-1 viremia. Risk groups for HHpgV-1 infection included intravenous drug users, blood product recipients, tattoo recipients, and men who have sex with men. Viral sequences clustered into 2 distinct HHpgV-1 genogroups. Cases had a higher mean HCV viral load than controls, with difference between means of 0.58 log10 IU/mL (P = .009). Cases were more likely to have an HCV viral load >5 log10 IU/mL (P = .028). Multiple regression demonstrated the impact of HHpgV-1 viral load and infection status on HCV viral load. HHpgV-1 infection was not associated with higher liver function tests, fibrosis scores, or imaging abnormalities. Conclusions: HHpgV-1 viremia is associated with a higher HCV viral load in co-infected patients. HHpgV-1 infection does not affect progression of HCV-related liver disease. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press (OUP): Policy C. The Journal's web site is located at http://ofid.oxfordjournals.org/ | - |
dc.relation.ispartof | Open Forum Infectious Diseases | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | hepatitis C virus | - |
dc.subject | human hepegivirus 1 | - |
dc.subject | hepatitis | - |
dc.title | Epidemiological and Clinical Characteristics of Human Hepegivirus 1 Infection in Patients With Hepatitis C | - |
dc.type | Article | - |
dc.identifier.email | Sridhar, S: sid8998@hku.hk | - |
dc.identifier.email | Yip, CCY: yipcyril@hku.hk | - |
dc.identifier.email | Chew, NFS: chewnf@hku.hk | - |
dc.identifier.email | Wu, S: wss2017@hku.hk | - |
dc.identifier.email | Leung, KH: khl17@hku.hk | - |
dc.identifier.email | Chan, JFW: jfwchan@hku.hk | - |
dc.identifier.email | Cheng, VCC: vcccheng@hkucc.hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | Sridhar, S=rp02249 | - |
dc.identifier.authority | Yip, CCY=rp01721 | - |
dc.identifier.authority | Chan, JFW=rp01736 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1093/ofid/ofz329 | - |
dc.identifier.scopus | eid_2-s2.0-85081760397 | - |
dc.identifier.hkuros | 310966 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | article no. ofz329 | - |
dc.identifier.epage | article no. ofz329 | - |
dc.identifier.isi | WOS:000484139700007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2328-8957 | - |