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Article: A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals

TitleA Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals
Authors
Keywordsbioimaging
chemiluminescence
hydrogen peroxide
imaging agents
fluorescent probes
Issue Date2020
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie (International Edition), 2020, Epub 2020-05-29 How to Cite?
AbstractSelective and sensitive molecular probes for hydrogen peroxide (H2O2), which plays diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the physiological and pathological effects of H2O2. A lack of reliable tools for in vivo imaging has hampered the development of H2O2 mediated therapeutics. By combining a specific tandem Payne/Dakin reaction with a chemiluminescent scaffold, H2O2‐CL‐510 was developed as a highly selective and sensitive probe for detection of H2O2 both in vitro and in vivo. A rapid 430‐fold enhancement of chemiluminescence was triggered directly by H2O2 without any laser excitation. Arsenic trioxide induced oxidative damage in leukemia was successfully detected. In particular, cerebral ischemia‐reperfusion injury‐induced H2O2 fluxes were visualized in rat brains using H2O2‐CL‐510 , providing a new chemical tool for real‐time monitoring of H2O2 dynamics in living animals.
Persistent Identifierhttp://hdl.handle.net/10722/284017
ISSN
2019 Impact Factor: 12.959
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYe, S-
dc.contributor.authorHananya, N-
dc.contributor.authorGreen, O-
dc.contributor.authorChen, H-
dc.contributor.authorZHAO, AQ-
dc.contributor.authorShen, J-
dc.contributor.authorShabat, D-
dc.contributor.authorYang, D-
dc.date.accessioned2020-07-20T05:55:21Z-
dc.date.available2020-07-20T05:55:21Z-
dc.date.issued2020-
dc.identifier.citationAngewandte Chemie (International Edition), 2020, Epub 2020-05-29-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/284017-
dc.description.abstractSelective and sensitive molecular probes for hydrogen peroxide (H2O2), which plays diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the physiological and pathological effects of H2O2. A lack of reliable tools for in vivo imaging has hampered the development of H2O2 mediated therapeutics. By combining a specific tandem Payne/Dakin reaction with a chemiluminescent scaffold, H2O2‐CL‐510 was developed as a highly selective and sensitive probe for detection of H2O2 both in vitro and in vivo. A rapid 430‐fold enhancement of chemiluminescence was triggered directly by H2O2 without any laser excitation. Arsenic trioxide induced oxidative damage in leukemia was successfully detected. In particular, cerebral ischemia‐reperfusion injury‐induced H2O2 fluxes were visualized in rat brains using H2O2‐CL‐510 , providing a new chemical tool for real‐time monitoring of H2O2 dynamics in living animals.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.subjectbioimaging-
dc.subjectchemiluminescence-
dc.subjecthydrogen peroxide-
dc.subjectimaging agents-
dc.subjectfluorescent probes-
dc.titleA Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals-
dc.typeArticle-
dc.identifier.emailYe, S: yesen@hku.hk-
dc.identifier.emailShen, J: shenjg@hku.hk-
dc.identifier.emailYang, D: yangdan@hku.hk-
dc.identifier.authorityShen, J=rp00487-
dc.identifier.authorityYang, D=rp00825-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.202005429-
dc.identifier.pmid32472602-
dc.identifier.scopuseid_2-s2.0-85087182086-
dc.identifier.hkuros311044-
dc.identifier.volumeEpub 2020-05-29-
dc.identifier.isiWOS:000544371100001-
dc.publisher.placeGermany-
dc.identifier.issnl1433-7851-

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