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- Publisher Website: 10.1021/acs.orglett.0c01544
- Scopus: eid_2-s2.0-85086748733
- PMID: 32484680
- WOS: WOS:000543669800031
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Article: Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation
Title | Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation |
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Authors | |
Keywords | Glycopeptide Eremomycin Teicoplanin |
Issue Date | 2020 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html |
Citation | Organic Letters, 2020, v. 22 n. 12, p. 4749-4753 How to Cite? |
Abstract | A convergent synthesis via the late-stage serine ligation of naturally occurring calcium-dependent antibiotic CDA3a and its analogues has been developed, which allowed us to readily synthesize the analogues with the variation on the lipid tail. Some analogues were found to show 100–500-fold higher antimicrobial activity than the natural compound CDA3a against drug resistant bacteria. This study will enhance our understanding of CDA3a and provide valuable antibacterial lead candidates for further development. |
Persistent Identifier | http://hdl.handle.net/10722/284012 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.245 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, D | - |
dc.contributor.author | Po, KHL | - |
dc.contributor.author | Blasco Morales, P | - |
dc.contributor.author | Chen, S | - |
dc.contributor.author | Li, X | - |
dc.date.accessioned | 2020-07-20T05:55:19Z | - |
dc.date.available | 2020-07-20T05:55:19Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Organic Letters, 2020, v. 22 n. 12, p. 4749-4753 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284012 | - |
dc.description.abstract | A convergent synthesis via the late-stage serine ligation of naturally occurring calcium-dependent antibiotic CDA3a and its analogues has been developed, which allowed us to readily synthesize the analogues with the variation on the lipid tail. Some analogues were found to show 100–500-fold higher antimicrobial activity than the natural compound CDA3a against drug resistant bacteria. This study will enhance our understanding of CDA3a and provide valuable antibacterial lead candidates for further development. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html | - |
dc.relation.ispartof | Organic Letters | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.subject | Glycopeptide | - |
dc.subject | Eremomycin | - |
dc.subject | Teicoplanin | - |
dc.title | Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation | - |
dc.type | Article | - |
dc.identifier.email | Chen, D: delinc@hku.hk | - |
dc.identifier.email | Blasco Morales, P: pbmoral@hku.hk | - |
dc.identifier.email | Li, X: xuechenl@hku.hk | - |
dc.identifier.authority | Li, X=rp00742 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.orglett.0c01544 | - |
dc.identifier.pmid | 32484680 | - |
dc.identifier.scopus | eid_2-s2.0-85086748733 | - |
dc.identifier.hkuros | 310983 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 4749 | - |
dc.identifier.epage | 4753 | - |
dc.identifier.isi | WOS:000543669800031 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1523-7052 | - |