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Article: Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation

TitleConvergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation
Authors
KeywordsGlycopeptide
Eremomycin
Teicoplanin
Issue Date2020
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html
Citation
Organic Letters, 2020, v. 22 n. 12, p. 4749-4753 How to Cite?
AbstractA convergent synthesis via the late-stage serine ligation of naturally occurring calcium-dependent antibiotic CDA3a and its analogues has been developed, which allowed us to readily synthesize the analogues with the variation on the lipid tail. Some analogues were found to show 100–500-fold higher antimicrobial activity than the natural compound CDA3a against drug resistant bacteria. This study will enhance our understanding of CDA3a and provide valuable antibacterial lead candidates for further development.
Persistent Identifierhttp://hdl.handle.net/10722/284012
ISSN
2019 Impact Factor: 6.091
2015 SCImago Journal Rankings: 3.187
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, D-
dc.contributor.authorPo, KHL-
dc.contributor.authorBlasco Morales, P-
dc.contributor.authorChen, S-
dc.contributor.authorLi, X-
dc.date.accessioned2020-07-20T05:55:19Z-
dc.date.available2020-07-20T05:55:19Z-
dc.date.issued2020-
dc.identifier.citationOrganic Letters, 2020, v. 22 n. 12, p. 4749-4753-
dc.identifier.issn1523-7060-
dc.identifier.urihttp://hdl.handle.net/10722/284012-
dc.description.abstractA convergent synthesis via the late-stage serine ligation of naturally occurring calcium-dependent antibiotic CDA3a and its analogues has been developed, which allowed us to readily synthesize the analogues with the variation on the lipid tail. Some analogues were found to show 100–500-fold higher antimicrobial activity than the natural compound CDA3a against drug resistant bacteria. This study will enhance our understanding of CDA3a and provide valuable antibacterial lead candidates for further development.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html-
dc.relation.ispartofOrganic Letters-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectGlycopeptide-
dc.subjectEremomycin-
dc.subjectTeicoplanin-
dc.titleConvergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation-
dc.typeArticle-
dc.identifier.emailChen, D: delinc@hku.hk-
dc.identifier.emailBlasco Morales, P: pbmoral@hku.hk-
dc.identifier.emailLi, X: xuechenl@hku.hk-
dc.identifier.authorityLi, X=rp00742-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.orglett.0c01544-
dc.identifier.pmid32484680-
dc.identifier.scopuseid_2-s2.0-85086748733-
dc.identifier.hkuros310983-
dc.identifier.volume22-
dc.identifier.issue12-
dc.identifier.spage4749-
dc.identifier.epage4753-
dc.identifier.isiWOS:000543669800031-
dc.publisher.placeUnited States-
dc.identifier.issnl1523-7052-

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