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Conference Paper: Deep brain stimulation of the prelimbic cortex disrupts consolidation of fear memories

TitleDeep brain stimulation of the prelimbic cortex disrupts consolidation of fear memories
Authors
Issue Date2019
PublisherElsevier BV. The Journal's web site is located at https://www.journals.elsevier.com/ibro-reports/
Citation
The 10th World Congress of Neuroscience (International Brain Research Organization; IBRO 2019), Daegu, Korea, 21-25 September 2019. In IBRO Reports, 2019, v. 6 n. Suppl., p. S66, abstract no.P00.38 How to Cite?
AbstractAnxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy, and toxicity. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of DBS on fear memories. In this study, we used a modified plus-maze discriminative task and showed that DBS of the prelimbic cortex was able to disrupt consolidation, but not acquisition or retrieval of avoidance fear memories. These results were further extended to conditioned fear memories using a standard tone-footshock fear conditioning paradigm and we demonstrated that the mechanisms were mediated by dopaminergic modulation and changes of specific neurotransmission and their metabolites in the ventral hippocampus. In conclusion, our study establishes a partial causal role of dopamine 2 receptor on the potential therapeutic role of prelimbic cortex DBS to treat anxiety disorders.
Descriptionno. P00.38
Persistent Identifierhttp://hdl.handle.net/10722/283316
ISSN

 

DC FieldValueLanguage
dc.contributor.authorTan, S-
dc.contributor.authorPoon, CH-
dc.contributor.authorChan, YS-
dc.contributor.authorLim, LW-
dc.date.accessioned2020-06-22T02:54:56Z-
dc.date.available2020-06-22T02:54:56Z-
dc.date.issued2019-
dc.identifier.citationThe 10th World Congress of Neuroscience (International Brain Research Organization; IBRO 2019), Daegu, Korea, 21-25 September 2019. In IBRO Reports, 2019, v. 6 n. Suppl., p. S66, abstract no.P00.38-
dc.identifier.issn2451-8301-
dc.identifier.urihttp://hdl.handle.net/10722/283316-
dc.descriptionno. P00.38-
dc.description.abstractAnxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy, and toxicity. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of DBS on fear memories. In this study, we used a modified plus-maze discriminative task and showed that DBS of the prelimbic cortex was able to disrupt consolidation, but not acquisition or retrieval of avoidance fear memories. These results were further extended to conditioned fear memories using a standard tone-footshock fear conditioning paradigm and we demonstrated that the mechanisms were mediated by dopaminergic modulation and changes of specific neurotransmission and their metabolites in the ventral hippocampus. In conclusion, our study establishes a partial causal role of dopamine 2 receptor on the potential therapeutic role of prelimbic cortex DBS to treat anxiety disorders.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at https://www.journals.elsevier.com/ibro-reports/-
dc.relation.ispartofIBRO Reports-
dc.relation.ispartofIBRO 2019: IBRO World Congress of Neuroscience-
dc.titleDeep brain stimulation of the prelimbic cortex disrupts consolidation of fear memories-
dc.typeConference_Paper-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ibror.2019.07.217-
dc.identifier.hkuros310461-
dc.identifier.volume6-
dc.identifier.issueSuppl.-
dc.identifier.spageS66, abstract no.P00.38-
dc.identifier.epageS66, abstract no.P00.38-
dc.publisher.placeNetherlands-

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