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Article: Protracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice
Title | Protracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice |
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Authors | |
Keywords | intracerebral hemorrhage hemorrhagic stroke corticospinal tract integrity spinal cord changes collagenase mice model |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience |
Citation | Frontiers in Neuroscience, 2020, v. 14, p. article no. 506 How to Cite? |
Abstract | Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. Currently, there is no promising treatment that improves prognosis significantly. While a thorough investigation of the pathological process within the primary site of injury in the brain has been conducted by the research field, the focus was mainly on gray matter injury, which partly accounted for the failure of discovery of clinically efficacious treatments. It is not until recent years that white matter (WM) injury in the brain after subcortical ICH was examined. As WM tracts form networks between different regions, damage to fibers should impair brain connectivity, resulting in functional impairment. Although WM changes have been demonstrated in the brain after ICH, alterations distant from the initial injury site down in the spinal cord are unclear. This longitudinal study, for the first time, revealed prolonged morphological changes of the contralesional dorsal corticospinal tract (CST) in the spinal cord 5 weeks after experimental ICH in mice by confocal microscopy and transmission electron microscopy, implying that the structural integrity of the CST was compromised extensively after ICH. Given the important role of CST in motor function, future translational studies targeting motor recovery should delineate the treatment effects on CST integrity. |
Persistent Identifier | http://hdl.handle.net/10722/283243 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.063 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | NG, ACK | - |
dc.contributor.author | YAO, M | - |
dc.contributor.author | CHENG, SY | - |
dc.contributor.author | LI, J | - |
dc.contributor.author | Huang, JD | - |
dc.contributor.author | Wu, W | - |
dc.contributor.author | Leung, GKK | - |
dc.contributor.author | Sun, H | - |
dc.date.accessioned | 2020-06-22T02:54:02Z | - |
dc.date.available | 2020-06-22T02:54:02Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Neuroscience, 2020, v. 14, p. article no. 506 | - |
dc.identifier.issn | 1662-453X | - |
dc.identifier.uri | http://hdl.handle.net/10722/283243 | - |
dc.description.abstract | Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. Currently, there is no promising treatment that improves prognosis significantly. While a thorough investigation of the pathological process within the primary site of injury in the brain has been conducted by the research field, the focus was mainly on gray matter injury, which partly accounted for the failure of discovery of clinically efficacious treatments. It is not until recent years that white matter (WM) injury in the brain after subcortical ICH was examined. As WM tracts form networks between different regions, damage to fibers should impair brain connectivity, resulting in functional impairment. Although WM changes have been demonstrated in the brain after ICH, alterations distant from the initial injury site down in the spinal cord are unclear. This longitudinal study, for the first time, revealed prolonged morphological changes of the contralesional dorsal corticospinal tract (CST) in the spinal cord 5 weeks after experimental ICH in mice by confocal microscopy and transmission electron microscopy, implying that the structural integrity of the CST was compromised extensively after ICH. Given the important role of CST in motor function, future translational studies targeting motor recovery should delineate the treatment effects on CST integrity. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience | - |
dc.relation.ispartof | Frontiers in Neuroscience | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | intracerebral hemorrhage | - |
dc.subject | hemorrhagic stroke | - |
dc.subject | corticospinal tract integrity | - |
dc.subject | spinal cord changes | - |
dc.subject | collagenase mice model | - |
dc.title | Protracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice | - |
dc.type | Article | - |
dc.identifier.email | Huang, JD: jdhuang@hku.hk | - |
dc.identifier.email | Leung, GKK: gkkleung@hku.hk | - |
dc.identifier.email | Sun, H: haitao88@hku.hk | - |
dc.identifier.authority | Huang, JD=rp00451 | - |
dc.identifier.authority | Wu, W=rp00419 | - |
dc.identifier.authority | Leung, GKK=rp00522 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fnins.2020.00506 | - |
dc.identifier.scopus | eid_2-s2.0-85086775728 | - |
dc.identifier.hkuros | 310392 | - |
dc.identifier.volume | 14 | - |
dc.identifier.spage | article no. 506 | - |
dc.identifier.epage | article no. 506 | - |
dc.identifier.isi | WOS:000543126800001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1662-453X | - |