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Article: Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood

TitleTrust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood
Authors
Keywordsadult
adulthood
bivariate analysis
bootstrapping
child sexual abuse
Issue Date2020
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2020, v. 15, p. article no. e0232932 How to Cite?
AbstractChildhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health outcomes, but the mediating role of trust in partners in the association between CSA and inflammation in adulthood requires further study. The present study aimed to examine the impact of CSA on inflammatory biomarkers (IL-6 and IL-1β) in adults with depression and the mediating role of trust. A cross-sectional survey data set of adults presenting with mood and sleep disturbance was used in the analysis. CSA demonstrated a significant negative correlation with IL-6 level (r=-.28, p<. 01) in adults with clinically significant depression, while trust showed a significant positive correlation with IL-6 level (r=.36, p<.01). Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. CSA and trust in partners were revealed to have significant associations with IL-6 level in adulthood. Counterintuitively, the directions of association were not those expected. Trust played a mediating role between CSA and adulthood levels of IL-6. Plausible explanations for these counterintuitive findings are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/282961
ISSN
2019 Impact Factor: 2.74
2015 SCImago Journal Rankings: 1.395
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorNg, SM-
dc.contributor.authorLENG, LL-
dc.contributor.authorXIE, Q-
dc.contributor.authorChan, JSM-
dc.contributor.authorChan, CHY-
dc.contributor.authorSo, KF-
dc.contributor.authorLi, A-
dc.contributor.authorPo, KKT-
dc.contributor.authorYuen, LP-
dc.contributor.authorKu, KS-
dc.contributor.authorChoi, AWM-
dc.contributor.authorChouliara, Z-
dc.contributor.authorCheung, ACY-
dc.contributor.authorChan, CLW-
dc.contributor.authorEmery, C-
dc.contributor.authorSantana, GL-
dc.date.accessioned2020-06-05T06:23:32Z-
dc.date.available2020-06-05T06:23:32Z-
dc.date.issued2020-
dc.identifier.citationPLoS One, 2020, v. 15, p. article no. e0232932-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/282961-
dc.description.abstractChildhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health outcomes, but the mediating role of trust in partners in the association between CSA and inflammation in adulthood requires further study. The present study aimed to examine the impact of CSA on inflammatory biomarkers (IL-6 and IL-1β) in adults with depression and the mediating role of trust. A cross-sectional survey data set of adults presenting with mood and sleep disturbance was used in the analysis. CSA demonstrated a significant negative correlation with IL-6 level (r=-.28, p<. 01) in adults with clinically significant depression, while trust showed a significant positive correlation with IL-6 level (r=.36, p<.01). Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. CSA and trust in partners were revealed to have significant associations with IL-6 level in adulthood. Counterintuitively, the directions of association were not those expected. Trust played a mediating role between CSA and adulthood levels of IL-6. Plausible explanations for these counterintuitive findings are discussed.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS One-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadult-
dc.subjectadulthood-
dc.subjectbivariate analysis-
dc.subjectbootstrapping-
dc.subjectchild sexual abuse-
dc.titleTrust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood-
dc.typeArticle-
dc.identifier.emailNg, SM: ngsiuman@hku.hk-
dc.identifier.emailChan, CHY: chancelia@hku.hk-
dc.identifier.emailChan, CLW: cecichan@hku.hk-
dc.identifier.emailEmery, C: cemery@hku.hk-
dc.identifier.authorityNg, SM=rp00611-
dc.identifier.authorityChan, CHY=rp00498-
dc.identifier.authorityChan, CLW=rp00579-
dc.identifier.authorityEmery, C=rp02302-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0232932-
dc.identifier.pmid32413063-
dc.identifier.pmcidPMC7228092-
dc.identifier.scopuseid_2-s2.0-85084785657-
dc.identifier.hkuros310120-
dc.identifier.volume15-
dc.identifier.spagearticle no. e0232932-
dc.identifier.epagearticle no. e0232932-
dc.publisher.placeUnited States-

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