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- Publisher Website: 10.1109/TNANO.2018.2882383
- Scopus: eid_2-s2.0-85057874006
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Article: Atomic Force Microscopy in Probing Tumor Physics for Nanomedicine
Title | Atomic Force Microscopy in Probing Tumor Physics for Nanomedicine |
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Authors | |
Keywords | Tumors Cancer Force Imaging Extracellular |
Issue Date | 2018 |
Publisher | IEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7729 |
Citation | IEEE Transactions on Nanotechnology, 2018, v. 18, p. 83-113 How to Cite? |
Abstract | Investigating the physics in tumor development and progression has been recognized as a promising way to advance both basic cancer research and clinical cancer treatment. The advent of atomic force microscopy (AFM) provides an exciting multifunctional tool for investigating the physical properties of biological systems under aqueous conditions with unprecedented spatiotemporal resolution, opening new possibilities for nanomedicine in physical oncology. In this paper, the biomedical applications of AFM to investigate the physical sciences in oncology at single-cell, single-molecule, and tissue levels are systematically reviewed, taking lymphomas as an example. First, detecting the physics of cancers at multiple scales is summarized, along with antibody-based therapy for lymphomas. Next, the principles and methods of AFM imaging and measurements are summarized. After that, utilizing AFM to probe the physics of tumors is reviewed from several facets, including topographical imaging, mechanical measurement, molecular recognition, primary cell detection, and tissue characterization. In particular, the motivations and state-of-the-art overviews of each facet are presented. Finally, the current limitations and future directions of AFM assays for cancer investigations are discussed. |
Persistent Identifier | http://hdl.handle.net/10722/282928 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.435 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, M | - |
dc.contributor.author | Xi, N | - |
dc.contributor.author | WANG, Y | - |
dc.contributor.author | LIU, L | - |
dc.date.accessioned | 2020-06-05T06:23:09Z | - |
dc.date.available | 2020-06-05T06:23:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | IEEE Transactions on Nanotechnology, 2018, v. 18, p. 83-113 | - |
dc.identifier.issn | 1536-125X | - |
dc.identifier.uri | http://hdl.handle.net/10722/282928 | - |
dc.description.abstract | Investigating the physics in tumor development and progression has been recognized as a promising way to advance both basic cancer research and clinical cancer treatment. The advent of atomic force microscopy (AFM) provides an exciting multifunctional tool for investigating the physical properties of biological systems under aqueous conditions with unprecedented spatiotemporal resolution, opening new possibilities for nanomedicine in physical oncology. In this paper, the biomedical applications of AFM to investigate the physical sciences in oncology at single-cell, single-molecule, and tissue levels are systematically reviewed, taking lymphomas as an example. First, detecting the physics of cancers at multiple scales is summarized, along with antibody-based therapy for lymphomas. Next, the principles and methods of AFM imaging and measurements are summarized. After that, utilizing AFM to probe the physics of tumors is reviewed from several facets, including topographical imaging, mechanical measurement, molecular recognition, primary cell detection, and tissue characterization. In particular, the motivations and state-of-the-art overviews of each facet are presented. Finally, the current limitations and future directions of AFM assays for cancer investigations are discussed. | - |
dc.language | eng | - |
dc.publisher | IEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7729 | - |
dc.relation.ispartof | IEEE Transactions on Nanotechnology | - |
dc.rights | IEEE Transactions on Nanotechnology. Copyright © IEEE. | - |
dc.rights | ©20xx IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | - |
dc.subject | Tumors | - |
dc.subject | Cancer | - |
dc.subject | Force | - |
dc.subject | Imaging | - |
dc.subject | Extracellular | - |
dc.title | Atomic Force Microscopy in Probing Tumor Physics for Nanomedicine | - |
dc.type | Article | - |
dc.identifier.email | Xi, N: xining@hku.hk | - |
dc.identifier.authority | Xi, N=rp02044 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1109/TNANO.2018.2882383 | - |
dc.identifier.scopus | eid_2-s2.0-85057874006 | - |
dc.identifier.hkuros | 310096 | - |
dc.identifier.volume | 18 | - |
dc.identifier.spage | 83 | - |
dc.identifier.epage | 113 | - |
dc.identifier.isi | WOS:000455709300011 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1536-125X | - |