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Article: A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients

TitleA randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients
Authors
Keywordscardiac function
diabetes mellitus
echocardiography
periodontitis
randomized clinical trial
Issue Date2020
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X
Citation
Journal of Clinical Periodontology, 2020, v. 47 n. 6, p. 726-736 How to Cite?
AbstractBackground: Periodontitis significantly increases the risk of diabetic complications. This clinical trial investigated the effects of periodontal therapy on cardiac function in patients with type 2 diabetes mellitus (T2DM) and periodontitis. Materials and methods: Fifty‐eight subjects with T2DM and periodontitis were randomly allocated to Treatment Group (n = 29) receiving non‐surgical periodontal therapy, and Control Group (n = 29) having only oral hygiene instructions with delayed periodontal treatment until completion of this 6‐month study. The left ventricle (LV) diastolic function was assessed by echocardiography with the tissue Doppler imaging index (E/e' ratio); and LV hypertrophy was evaluated by LV mass index (LVMI). Blood samples were collected for biochemical analysis. Results: The intention‐to‐treat analysis showed that periodontal treatment significantly reduced the E/e' ratio by 1.66 (95% CI: −2.64 to −0.68, p < .01), along with marked improvement of periodontal conditions (p < .05). LVMI was not altered at the 6‐month follow‐up. The serum levels of N‐terminal pro‐B type natriuretic peptide (NT‐proBNP) as a cardiac stress biomarker, C‐reactive protein and interleukin‐6 decreased numerically without reaching statistical significance. Conclusion: The present study provides the first evidence that non‐surgical periodontal therapy may improve cardiac diastolic function in type 2 diabetic patients with periodontitis.
Persistent Identifierhttp://hdl.handle.net/10722/282874
ISSN
2019 Impact Factor: 5.241
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWANG, Y-
dc.contributor.authorLiu, HN-
dc.contributor.authorZhen, Z-
dc.contributor.authorPelekos, G-
dc.contributor.authorWu, MZ-
dc.contributor.authorChen, Y-
dc.contributor.authorTonetti, M-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.contributor.authorJin, L-
dc.date.accessioned2020-06-05T06:22:33Z-
dc.date.available2020-06-05T06:22:33Z-
dc.date.issued2020-
dc.identifier.citationJournal of Clinical Periodontology, 2020, v. 47 n. 6, p. 726-736-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/282874-
dc.description.abstractBackground: Periodontitis significantly increases the risk of diabetic complications. This clinical trial investigated the effects of periodontal therapy on cardiac function in patients with type 2 diabetes mellitus (T2DM) and periodontitis. Materials and methods: Fifty‐eight subjects with T2DM and periodontitis were randomly allocated to Treatment Group (n = 29) receiving non‐surgical periodontal therapy, and Control Group (n = 29) having only oral hygiene instructions with delayed periodontal treatment until completion of this 6‐month study. The left ventricle (LV) diastolic function was assessed by echocardiography with the tissue Doppler imaging index (E/e' ratio); and LV hypertrophy was evaluated by LV mass index (LVMI). Blood samples were collected for biochemical analysis. Results: The intention‐to‐treat analysis showed that periodontal treatment significantly reduced the E/e' ratio by 1.66 (95% CI: −2.64 to −0.68, p < .01), along with marked improvement of periodontal conditions (p < .05). LVMI was not altered at the 6‐month follow‐up. The serum levels of N‐terminal pro‐B type natriuretic peptide (NT‐proBNP) as a cardiac stress biomarker, C‐reactive protein and interleukin‐6 decreased numerically without reaching statistical significance. Conclusion: The present study provides the first evidence that non‐surgical periodontal therapy may improve cardiac diastolic function in type 2 diabetic patients with periodontitis.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcardiac function-
dc.subjectdiabetes mellitus-
dc.subjectechocardiography-
dc.subjectperiodontitis-
dc.subjectrandomized clinical trial-
dc.titleA randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients-
dc.typeArticle-
dc.identifier.emailLiu, HN: drdhnl@hku.hk-
dc.identifier.emailZhen, Z: zhenzhe@hku.hk-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.emailChen, Y: cheny818@hku.hk-
dc.identifier.emailTonetti, M: tonetti@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.authorityTonetti, M=rp02178-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityJin, L=rp00028-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jcpe.13291-
dc.identifier.pmid32350903-
dc.identifier.scopuseid_2-s2.0-85083987375-
dc.identifier.hkuros310240-
dc.identifier.volume47-
dc.identifier.issue6-
dc.identifier.spage726-
dc.identifier.epage736-
dc.identifier.isiWOS:000529646900001-
dc.publisher.placeUnited States-
dc.identifier.issnl0303-6979-

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