File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Roles of microRNAs as non-invasive biomarker and therapeutic target in colorectal cancer

TitleRoles of microRNAs as non-invasive biomarker and therapeutic target in colorectal cancer
Authors
KeywordsmiRNA
Colorectal cancer
Biomarker
Therapy
Issue Date2020
PublisherUniversidad de Murcia, Departamento de Biologia Celular e Histologia. The Journal's web site is located at http://www.hh.um.es
Citation
Histology and Histopathology: From Cell Biology to Tissue Engineering, 2020, v. 35 n. 3, p. 225-237 How to Cite?
AbstractMicroRNAs are endogenous, short non-coding RNA molecules that function as critical regulators of various biological processes. There is a strong functional evidence linking the involvement of dysregulated miRNAs to the occurrence, development and progression of colorectal cancer. Studies indicate that while overexpression of oncomiRs, and repression of tumor suppressor miRNAs tends to drive the overall tumorigenic process, the global picture of aberrant miRNA expression in colorectal cancer can classify the disease into multiple molecular phenotypes. Moreover, the expression pattern of miRNAs in colorectal cancer makes them viable disease determinants as well as potential therapeutic targets. Through this review, we will summarize the importance of miRNAs in the etiology and progression of colorectal cancer. Specifically, we will explore the key role played by these RNA molecules as likely therapeutic avenues and the strategies presently available to target them. Finally, we will investigate the role of miRNAs as potential non-invasive diagnostic and prognostic biomarkers in colorectal cancer.
Persistent Identifierhttp://hdl.handle.net/10722/281899
ISSN
2019 Impact Factor: 2.021
2015 SCImago Journal Rankings: 0.805

 

DC FieldValueLanguage
dc.contributor.authorWan, TMH-
dc.contributor.authorIyer, DN-
dc.contributor.authorNg, L-
dc.date.accessioned2020-04-03T07:23:22Z-
dc.date.available2020-04-03T07:23:22Z-
dc.date.issued2020-
dc.identifier.citationHistology and Histopathology: From Cell Biology to Tissue Engineering, 2020, v. 35 n. 3, p. 225-237-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10722/281899-
dc.description.abstractMicroRNAs are endogenous, short non-coding RNA molecules that function as critical regulators of various biological processes. There is a strong functional evidence linking the involvement of dysregulated miRNAs to the occurrence, development and progression of colorectal cancer. Studies indicate that while overexpression of oncomiRs, and repression of tumor suppressor miRNAs tends to drive the overall tumorigenic process, the global picture of aberrant miRNA expression in colorectal cancer can classify the disease into multiple molecular phenotypes. Moreover, the expression pattern of miRNAs in colorectal cancer makes them viable disease determinants as well as potential therapeutic targets. Through this review, we will summarize the importance of miRNAs in the etiology and progression of colorectal cancer. Specifically, we will explore the key role played by these RNA molecules as likely therapeutic avenues and the strategies presently available to target them. Finally, we will investigate the role of miRNAs as potential non-invasive diagnostic and prognostic biomarkers in colorectal cancer.-
dc.languageeng-
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histologia. The Journal's web site is located at http://www.hh.um.es-
dc.relation.ispartofHistology and Histopathology: From Cell Biology to Tissue Engineering-
dc.subjectmiRNA-
dc.subjectColorectal cancer-
dc.subjectBiomarker-
dc.subjectTherapy-
dc.titleRoles of microRNAs as non-invasive biomarker and therapeutic target in colorectal cancer-
dc.typeArticle-
dc.identifier.emailWan, TMH: tmhwan@hku.hk-
dc.identifier.emailIyer, DN: deeiyer@hku.hk-
dc.identifier.emailNg, L: luing@hku.hk-
dc.identifier.authorityNg, L=rp02207-
dc.description.naturepostprint-
dc.identifier.doi10.14670/HH-18-171-
dc.identifier.pmid31617575-
dc.identifier.scopuseid_2-s2.0-85080834652-
dc.identifier.hkuros309611-
dc.identifier.hkuros311360-
dc.identifier.volume35-
dc.identifier.issue3-
dc.identifier.spage225-
dc.identifier.epage237-
dc.publisher.placeSpain-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats