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Article: Enzyme-Mediated Mineralization of TiO2 Nanotubes Subjected to Different Heat Treatments

TitleEnzyme-Mediated Mineralization of TiO2 Nanotubes Subjected to Different Heat Treatments
Authors
KeywordsBone
Calcium phosphate
Coatings
Enzymes
Heat treatment
Issue Date2019
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crystal
Citation
Crystal Growth & Design, 2019, v. 19, p. 7112-7121 How to Cite?
AbstractSurface-modified titanium (Ti) and titanium alloys with physical topography and bioactive components mimicking those of bone tissues have attracted increasing interest as biomaterials for accelerating osseointegration. In this study, an enzyme-mediated mineralization system containing an organic phosphate is used to form a coating of calcium phosphate on titanium dioxide (TiO2) nanotubes heat-treated at different temperatures (350, 450, and 550 °C). Surface characterization using analytical techniques shows that this system can lead to the deposition of an amorphous calcium phosphate layer on the TiO2 nanotube (TNT) surface while preserving the original nanotopography. In this respect, the heat treatment of TNT plays an essential role in the formation of the calcium phosphate layer, with TNT annealed at 450 °C having the best mineralization results. The synergistic effect of the TNT topography and chemical cues of the calcium phosphate layer improves adhesion, proliferation, and differentiation of pre-osteoblasts in vitro when compared with surfaces with only one of these features. This hybrid coating can thus potentially enhance the osseointegration of titanium-based implants.
Persistent Identifierhttp://hdl.handle.net/10722/281793
ISSN
2019 Impact Factor: 4.089
2015 SCImago Journal Rankings: 1.328

 

DC FieldValueLanguage
dc.contributor.authorYUN, J-
dc.contributor.authorWu, J-
dc.contributor.authorAparicio, C-
dc.contributor.authorTsoi, JKH-
dc.contributor.authorWang, Y-
dc.contributor.authorFok, A-
dc.date.accessioned2020-03-27T04:22:35Z-
dc.date.available2020-03-27T04:22:35Z-
dc.date.issued2019-
dc.identifier.citationCrystal Growth & Design, 2019, v. 19, p. 7112-7121-
dc.identifier.issn1528-7483-
dc.identifier.urihttp://hdl.handle.net/10722/281793-
dc.description.abstractSurface-modified titanium (Ti) and titanium alloys with physical topography and bioactive components mimicking those of bone tissues have attracted increasing interest as biomaterials for accelerating osseointegration. In this study, an enzyme-mediated mineralization system containing an organic phosphate is used to form a coating of calcium phosphate on titanium dioxide (TiO2) nanotubes heat-treated at different temperatures (350, 450, and 550 °C). Surface characterization using analytical techniques shows that this system can lead to the deposition of an amorphous calcium phosphate layer on the TiO2 nanotube (TNT) surface while preserving the original nanotopography. In this respect, the heat treatment of TNT plays an essential role in the formation of the calcium phosphate layer, with TNT annealed at 450 °C having the best mineralization results. The synergistic effect of the TNT topography and chemical cues of the calcium phosphate layer improves adhesion, proliferation, and differentiation of pre-osteoblasts in vitro when compared with surfaces with only one of these features. This hybrid coating can thus potentially enhance the osseointegration of titanium-based implants.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crystal-
dc.relation.ispartofCrystal Growth & Design-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectBone-
dc.subjectCalcium phosphate-
dc.subjectCoatings-
dc.subjectEnzymes-
dc.subjectHeat treatment-
dc.titleEnzyme-Mediated Mineralization of TiO2 Nanotubes Subjected to Different Heat Treatments-
dc.typeArticle-
dc.identifier.emailTsoi, JKH: jkhtsoi@hku.hk-
dc.identifier.authorityTsoi, JKH=rp01609-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.cgd.9b00966-
dc.identifier.scopuseid_2-s2.0-85074934636-
dc.identifier.hkuros309539-
dc.identifier.volume19-
dc.identifier.spage7112-
dc.identifier.epage7121-
dc.publisher.placeUnited States-

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