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Article: Effect of root canal debridement on inflammatory cytokine levels

TitleEffect of root canal debridement on inflammatory cytokine levels
Authors
Soh, JASheriff, SORamar, NAPPulikkotil, SJPNagendrababu, VNeelakantan, PAmalraj, FD
Keywordscytokine
inflammation
interleukin‐10
interleukin‐8
root canal therapy
Issue Date2019
PublisherWiley, published in association with Australian Society of Endodontology. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1747-4477
Citation
Australian Endodontic Journal, 2019, v. 45 n. 2, p. 171-176 How to Cite?
DOI: http://dx.doi.org/10.1111/aej.12303
AbstractIn endodontic infections, inflammatory mediators such as cytokines are released, recruited and retained until the infection is eradicated. Root canal therapy is performed to prevent the spread of infection. The aim of this study was to investigate the effects of root canal debridement (cleaning and shaping) on periapical inflammation by measuring the levels of inflammatory cytokines, Interleukin‐8 (IL‐8) and Interleukin‐10 (IL‐10). The study includes twenty patients with pulp necrosis and asymptomatic apical periodontitis. Periradicular sample was collected using paper points before and after root canal debridement. Cytokine levels were determined by Sandwich Enzyme‐Linked Immunosorbent Assay (ELISA). Data were analysed using paired t‐test (PASW Statistics 18) (P = 0.05). All samples showed the presence of IL‐8 and IL‐10 prior to root canal debridement. Significantly reduced levels (P < 0.05) of IL‐8 and IL‐10 were detected after root canal debridement. In conclusion, root canal debridement significantly decreased the levels of the tested pro‐ and anti‐inflammatory cytokine in the periradicular interstitial fluid.
Persistent Identifierhttp://hdl.handle.net/10722/281779
ISSN
1329-1947
2021 Impact Factor: 1.719
2020 SCImago Journal Rankings: 0.703
ISI Accession Number ID
WOS:000481524000006

 

DC FieldValueLanguage
dc.contributor.authorSoh, JA-
dc.contributor.authorSheriff, SO-
dc.contributor.authorRamar, NAP-
dc.contributor.authorPulikkotil, SJP-
dc.contributor.authorNagendrababu, V-
dc.contributor.authorNeelakantan, P-
dc.contributor.authorAmalraj, FD-
dc.date.accessioned2020-03-27T04:22:26Z-
dc.date.available2020-03-27T04:22:26Z-
dc.date.issued2019-
dc.identifier.citationAustralian Endodontic Journal, 2019, v. 45 n. 2, p. 171-176-
dc.identifier.issn1329-1947-
dc.identifier.urihttp://hdl.handle.net/10722/281779-
dc.description.abstractIn endodontic infections, inflammatory mediators such as cytokines are released, recruited and retained until the infection is eradicated. Root canal therapy is performed to prevent the spread of infection. The aim of this study was to investigate the effects of root canal debridement (cleaning and shaping) on periapical inflammation by measuring the levels of inflammatory cytokines, Interleukin‐8 (IL‐8) and Interleukin‐10 (IL‐10). The study includes twenty patients with pulp necrosis and asymptomatic apical periodontitis. Periradicular sample was collected using paper points before and after root canal debridement. Cytokine levels were determined by Sandwich Enzyme‐Linked Immunosorbent Assay (ELISA). Data were analysed using paired t‐test (PASW Statistics 18) (P = 0.05). All samples showed the presence of IL‐8 and IL‐10 prior to root canal debridement. Significantly reduced levels (P < 0.05) of IL‐8 and IL‐10 were detected after root canal debridement. In conclusion, root canal debridement significantly decreased the levels of the tested pro‐ and anti‐inflammatory cytokine in the periradicular interstitial fluid.-
dc.languageeng-
dc.publisherWiley, published in association with Australian Society of Endodontology. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1747-4477-
dc.relation.ispartofAustralian Endodontic Journal-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcytokine-
dc.subjectinflammation-
dc.subjectinterleukin‐10-
dc.subjectinterleukin‐8-
dc.subjectroot canal therapy-
dc.titleEffect of root canal debridement on inflammatory cytokine levels-
dc.typeArticle-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/aej.12303-
dc.identifier.pmid30230109-
dc.identifier.scopuseid_2-s2.0-85053549600-
dc.identifier.hkuros309494-
dc.identifier.volume45-
dc.identifier.issue2-
dc.identifier.spage171-
dc.identifier.epage176-
dc.identifier.isiWOS:000481524000006-
dc.publisher.placeAustralia-
dc.identifier.issnl1329-1947-

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