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Article: Predicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer

TitlePredicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer
Authors
KeywordsLung cancer
Neutropenia
Predictive models
Issue Date2020
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
Lung Cancer, 2020, v. 141, p. 14-20 How to Cite?
AbstractObjectives: Neutropenia is associated with the risk of life-threatening infections, chemotherapy dose reductions and delays that may compromise outcomes. This analysis was conducted to develop a prediction model for chemotherapy-induced severe neutropenia in lung cancer. Materials and Methods: Individual patient data from existing cooperative group phase II/III trials of stages III/IV non-small cell lung cancer or extensive small-cell lung cancer were included. The data were split into training and testing sets. In order to enhance the prediction accuracy and the reliability of the prediction model, lasso method was used for both variable selection and regularization on the training set. The selected variables was fit to a logistic model to obtain regression coefficients. The performance of the final prediction model was evaluated by the area under the ROC curve in both training and testing sets. Results: The dataset was randomly separated into training [7606 (67 %) patients] and testing [3746 (33 %) patients] sets. The final model included: age (>65 years), gender (male), weight (kg), BMI, insurance status (yes/unknown), stage (IIIB/IV/ESSCLC), number of metastatic sites (1, 2 or ≥3), individual drugs (gemcitabine, taxanes), number of chemotherapy agents (2 or ≥3), planned use of growth factors, associated radiation therapy, previous therapy (chemotherapy, radiation, surgery), duration of planned treatment, pleural effusion (yes/unknown), performance status (1, ≥2) and presence of symptoms (yes/unknown). Conclusions: We have developed a relatively simple model with routinely available pre-treatment variables, to predict for neutropenia. This model should be independently validated prospectively.
Persistent Identifierhttp://hdl.handle.net/10722/281770
ISSN
2017 Impact Factor: 4.486
2015 SCImago Journal Rankings: 1.923
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorCao, X-
dc.contributor.authorGanti, AK-
dc.contributor.authorStinchcombe, T-
dc.contributor.authorWong, ML-
dc.contributor.authorHo, JC-
dc.contributor.authorShen, C-
dc.contributor.authorLiu, Y-
dc.contributor.authorCrawford, J-
dc.contributor.authorPang, H-
dc.contributor.authorWang, X-
dc.date.accessioned2020-03-27T04:22:20Z-
dc.date.available2020-03-27T04:22:20Z-
dc.date.issued2020-
dc.identifier.citationLung Cancer, 2020, v. 141, p. 14-20-
dc.identifier.issn0169-5002-
dc.identifier.urihttp://hdl.handle.net/10722/281770-
dc.description.abstractObjectives: Neutropenia is associated with the risk of life-threatening infections, chemotherapy dose reductions and delays that may compromise outcomes. This analysis was conducted to develop a prediction model for chemotherapy-induced severe neutropenia in lung cancer. Materials and Methods: Individual patient data from existing cooperative group phase II/III trials of stages III/IV non-small cell lung cancer or extensive small-cell lung cancer were included. The data were split into training and testing sets. In order to enhance the prediction accuracy and the reliability of the prediction model, lasso method was used for both variable selection and regularization on the training set. The selected variables was fit to a logistic model to obtain regression coefficients. The performance of the final prediction model was evaluated by the area under the ROC curve in both training and testing sets. Results: The dataset was randomly separated into training [7606 (67 %) patients] and testing [3746 (33 %) patients] sets. The final model included: age (>65 years), gender (male), weight (kg), BMI, insurance status (yes/unknown), stage (IIIB/IV/ESSCLC), number of metastatic sites (1, 2 or ≥3), individual drugs (gemcitabine, taxanes), number of chemotherapy agents (2 or ≥3), planned use of growth factors, associated radiation therapy, previous therapy (chemotherapy, radiation, surgery), duration of planned treatment, pleural effusion (yes/unknown), performance status (1, ≥2) and presence of symptoms (yes/unknown). Conclusions: We have developed a relatively simple model with routinely available pre-treatment variables, to predict for neutropenia. This model should be independently validated prospectively.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan-
dc.relation.ispartofLung Cancer-
dc.subjectLung cancer-
dc.subjectNeutropenia-
dc.subjectPredictive models-
dc.titlePredicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer-
dc.typeArticle-
dc.identifier.emailHo, JC: jhocm@hku.hk-
dc.identifier.emailPang, H: herbpang@hku.hk-
dc.identifier.authorityHo, JC=rp00258-
dc.identifier.authorityPang, H=rp01857-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.lungcan.2020.01.004-
dc.identifier.pmid31926983-
dc.identifier.pmcidPMC7063587-
dc.identifier.scopuseid_2-s2.0-85077657547-
dc.identifier.hkuros309584-
dc.identifier.volume141-
dc.identifier.spage14-
dc.identifier.epage20-
dc.publisher.placeIreland-

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