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Article: Teriparatide in East Asian Postmenopausal Women with Osteoporosis in a Real-World Setting: A Baseline Analysis of the Asia and Latin America Fracture Observational Study (ALAFOS)

TitleTeriparatide in East Asian Postmenopausal Women with Osteoporosis in a Real-World Setting: A Baseline Analysis of the Asia and Latin America Fracture Observational Study (ALAFOS)
Authors
Keywordspostmenopausal osteoporosis
teriparatide
observational study
fractures
East Asia
Issue Date2020
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=4
Citation
Clinical Interventions in Aging, 2020, v. 2020 n. 15, p. 111-121 How to Cite?
AbstractPurpose: The aim of this analysis is to describe the baseline characteristics of patients who are prescribed teriparatide for the treatment of postmenopausal osteoporosis in a real-world setting in East Asia. Patients and Methods: The Asia and Latin America Fracture Observational Study (ALAFOS) is a prospective, multinational, observational study designed to evaluate real-world use of teriparatide in the treatment of postmenopausal osteoporosis in 20 countries across Asia, Latin America, the Middle East, and Russia. This subregional analysis focuses on the East Asian subpopulation of the ALAFOS study. Here we report baseline clinical characteristics, details regarding the history of fractures, risk factors for osteoporosis, comorbidities, osteoporosis treatment, and health-related quality of life in patients enrolled in China, Hong Kong, South Korea, and Taiwan. Results: The East Asian subgroup of ALAFOS included 1136 postmenopausal women, constituting 37.5% (1136/3031) of the overall ALAFOS patient population. The mean (SD) age was 75.0 (9.6) years. The mean (SD) bone mineral density T-scores were − 3.11 (1.54), − 2.58 (1.11), and − 2.86 (1.09) at the lumbar spine, total hip, and femoral neck, respectively; 69.6% of patients had experienced at least one fragility fracture and 40.4% had experienced ≥ 2 fragility fractures after 40 years of age. Overall, 63.3% of patients had used medications for osteoporosis in the past. The mean (SD) EQ-5D-5L Visual Analog Scale (VAS) score at baseline was 59.7 (20.8); the mean (SD) back pain numeric rating scale score for worst pain in the last 24 hrs was 5.2 (3.2). Conclusion: Our results indicate that patients who are prescribed teriparatide in East Asia were elderly women with severe osteoporosis, low bone mineral density, high prevalence of fractures, back pain and poor health-related quality of life. Most of the patients received teriparatide as a second-line treatment.
Persistent Identifierhttp://hdl.handle.net/10722/280968
ISSN
2013 Impact Factor: 1.824
2015 SCImago Journal Rankings: 0.865

 

DC FieldValueLanguage
dc.contributor.authorChen, CH-
dc.contributor.authorLim, SJ-
dc.contributor.authorOh, JK-
dc.contributor.authorHuang, TW-
dc.contributor.authorZeng, YH-
dc.contributor.authorWu, MT-
dc.contributor.authorYang, HL-
dc.contributor.authorCheung, JPY-
dc.contributor.authorKim, JW-
dc.contributor.authorHan, JH-
dc.contributor.authorHuo, L-
dc.contributor.authorLin, TJ-
dc.contributor.authorZhou, G-
dc.contributor.authorWu, WS-
dc.date.accessioned2020-02-25T07:43:24Z-
dc.date.available2020-02-25T07:43:24Z-
dc.date.issued2020-
dc.identifier.citationClinical Interventions in Aging, 2020, v. 2020 n. 15, p. 111-121-
dc.identifier.issn1176-9092-
dc.identifier.urihttp://hdl.handle.net/10722/280968-
dc.description.abstractPurpose: The aim of this analysis is to describe the baseline characteristics of patients who are prescribed teriparatide for the treatment of postmenopausal osteoporosis in a real-world setting in East Asia. Patients and Methods: The Asia and Latin America Fracture Observational Study (ALAFOS) is a prospective, multinational, observational study designed to evaluate real-world use of teriparatide in the treatment of postmenopausal osteoporosis in 20 countries across Asia, Latin America, the Middle East, and Russia. This subregional analysis focuses on the East Asian subpopulation of the ALAFOS study. Here we report baseline clinical characteristics, details regarding the history of fractures, risk factors for osteoporosis, comorbidities, osteoporosis treatment, and health-related quality of life in patients enrolled in China, Hong Kong, South Korea, and Taiwan. Results: The East Asian subgroup of ALAFOS included 1136 postmenopausal women, constituting 37.5% (1136/3031) of the overall ALAFOS patient population. The mean (SD) age was 75.0 (9.6) years. The mean (SD) bone mineral density T-scores were − 3.11 (1.54), − 2.58 (1.11), and − 2.86 (1.09) at the lumbar spine, total hip, and femoral neck, respectively; 69.6% of patients had experienced at least one fragility fracture and 40.4% had experienced ≥ 2 fragility fractures after 40 years of age. Overall, 63.3% of patients had used medications for osteoporosis in the past. The mean (SD) EQ-5D-5L Visual Analog Scale (VAS) score at baseline was 59.7 (20.8); the mean (SD) back pain numeric rating scale score for worst pain in the last 24 hrs was 5.2 (3.2). Conclusion: Our results indicate that patients who are prescribed teriparatide in East Asia were elderly women with severe osteoporosis, low bone mineral density, high prevalence of fractures, back pain and poor health-related quality of life. Most of the patients received teriparatide as a second-line treatment.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=4-
dc.relation.ispartofClinical Interventions in Aging-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectpostmenopausal osteoporosis-
dc.subjectteriparatide-
dc.subjectobservational study-
dc.subjectfractures-
dc.subjectEast Asia-
dc.titleTeriparatide in East Asian Postmenopausal Women with Osteoporosis in a Real-World Setting: A Baseline Analysis of the Asia and Latin America Fracture Observational Study (ALAFOS)-
dc.typeArticle-
dc.identifier.emailCheung, JPY: cheungjp@hku.hk-
dc.identifier.authorityCheung, JPY=rp01685-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/CIA.S228158-
dc.identifier.scopuseid_2-s2.0-85079447786-
dc.identifier.hkuros309165-
dc.identifier.volume2020-
dc.identifier.issue15-
dc.identifier.spage111-
dc.identifier.epage121-
dc.publisher.placeNew Zealand-

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