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Article: Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study

TitleAdiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study
Authors
KeywordsObesity
Body Mass Index
Obesity paradox
Issue Date2020
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2020, v. 10 n. 1, p. article no. 1924 How to Cite?
AbstractPrevious studies on Chinese showed mixed results describing the relationship between obesity and mortality. The optimum levels of body mass index (BMI) and waist circumference (WC) are inconsistent. In the Guangzhou Biobank Cohort Study, after excluding ever smokers and those with poor health, 19,405 Chinese (50+ years) recruited from 2003 to 2008 were followed-up until 2017. During an average follow-up of 11.5 (standard deviation = 2.3) years, 1,757 deaths were recorded. All-cause mortality showed a J-shaped association with BMI, with the lowest mortality risks at 22.5 kg/m2 for both men and women. In those with BMI ≥ 22.5 kg/m2, an increase of 5 kg/m2 was associated with 29% higher all-cause mortality (hazard ratio (HR) = 1.29, 95% confidence interval (CI) 1.15–1.46), 30% higher cancer mortality (1.30, 95% CI 1.08–1.57), and 37% higher cardiovascular disease (CVD) mortality (1.37, 95% CI 1.13–1.67) after adjustment for potential confounders. In this first cohort study in one of the most economically developed cities in China, the lowest all-cause mortality was observed for a BMI of 22.5 kg/m2 in all participants, and a WC of 78 cm in men and 72 cm in women.
Persistent Identifierhttp://hdl.handle.net/10722/280906
ISSN
2019 Impact Factor: 3.998
2015 SCImago Journal Rankings: 2.073
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, CQ-
dc.contributor.authorXu, L-
dc.contributor.authorZhang, WS-
dc.contributor.authorJin, YL-
dc.contributor.authorZhu, F-
dc.contributor.authorCheng, KK-
dc.contributor.authorLam, TH-
dc.date.accessioned2020-02-25T07:42:32Z-
dc.date.available2020-02-25T07:42:32Z-
dc.date.issued2020-
dc.identifier.citationScientific Reports, 2020, v. 10 n. 1, p. article no. 1924-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/280906-
dc.description.abstractPrevious studies on Chinese showed mixed results describing the relationship between obesity and mortality. The optimum levels of body mass index (BMI) and waist circumference (WC) are inconsistent. In the Guangzhou Biobank Cohort Study, after excluding ever smokers and those with poor health, 19,405 Chinese (50+ years) recruited from 2003 to 2008 were followed-up until 2017. During an average follow-up of 11.5 (standard deviation = 2.3) years, 1,757 deaths were recorded. All-cause mortality showed a J-shaped association with BMI, with the lowest mortality risks at 22.5 kg/m2 for both men and women. In those with BMI ≥ 22.5 kg/m2, an increase of 5 kg/m2 was associated with 29% higher all-cause mortality (hazard ratio (HR) = 1.29, 95% confidence interval (CI) 1.15–1.46), 30% higher cancer mortality (1.30, 95% CI 1.08–1.57), and 37% higher cardiovascular disease (CVD) mortality (1.37, 95% CI 1.13–1.67) after adjustment for potential confounders. In this first cohort study in one of the most economically developed cities in China, the lowest all-cause mortality was observed for a BMI of 22.5 kg/m2 in all participants, and a WC of 78 cm in men and 72 cm in women.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectObesity-
dc.subjectBody Mass Index-
dc.subjectObesity paradox-
dc.titleAdiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study-
dc.typeArticle-
dc.identifier.emailJiang, CQ: cqjiang@hkucc.hku.hk-
dc.identifier.emailXu, L: linxu@hku.hk-
dc.identifier.emailZhang, WS: zhangws9@hku.hk-
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.authorityXu, L=rp02030-
dc.identifier.authorityLam, TH=rp00326-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-020-58633-z-
dc.identifier.pmid32024868-
dc.identifier.pmcidPMC7002501-
dc.identifier.scopuseid_2-s2.0-85079047648-
dc.identifier.hkuros309196-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.spagearticle no. 1924-
dc.identifier.epagearticle no. 1924-
dc.publisher.placeUnited Kingdom-

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