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Article: Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers

TitleBiocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers
Authors
KeywordsBioimaging
Biomarking
Cancer cells
Confocal microscopy
Fluorescence nanoparticles
Magnesium oxide
Issue Date2019
PublisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/nanomaterials
Citation
Nanomaterials, 2019, v. 9 n. 10, article no. 1360, p. 1-16 How to Cite?
AbstractImaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial and in-house ball-milled MgO nanoparticles, respectively. As such, the NPs have been successfully integrated into cultured cells and photostable bright in vitro emission from NPs was recorded and analyzed. We expect that numerous biotechnological and medical applications will emerge as this nanomaterial satisfies all criteria for short-term in vivo imaging.
Persistent Identifierhttp://hdl.handle.net/10722/280035
ISSN
2018 Impact Factor: 4.034
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKhalid, A-
dc.contributor.authorNorello, R-
dc.contributor.authorAbraham, AN-
dc.contributor.authorTetienne, J-
dc.contributor.authorKarle, TJ-
dc.contributor.authorLui, EWC-
dc.contributor.authorXia, K-
dc.contributor.authorTran, PA-
dc.contributor.authorO’Connor, AJ-
dc.contributor.authorMann, BG-
dc.contributor.authorde Boer, R-
dc.contributor.authorHe, Y-
dc.contributor.authorNg, AMC-
dc.contributor.authorDjurisic, AB-
dc.contributor.authorShukla, R-
dc.contributor.authorTomljenovic-Hanic, S-
dc.date.accessioned2019-12-23T08:25:15Z-
dc.date.available2019-12-23T08:25:15Z-
dc.date.issued2019-
dc.identifier.citationNanomaterials, 2019, v. 9 n. 10, article no. 1360, p. 1-16-
dc.identifier.issn2079-4991-
dc.identifier.urihttp://hdl.handle.net/10722/280035-
dc.description.abstractImaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial and in-house ball-milled MgO nanoparticles, respectively. As such, the NPs have been successfully integrated into cultured cells and photostable bright in vitro emission from NPs was recorded and analyzed. We expect that numerous biotechnological and medical applications will emerge as this nanomaterial satisfies all criteria for short-term in vivo imaging.-
dc.languageeng-
dc.publisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/nanomaterials-
dc.relation.ispartofNanomaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBioimaging-
dc.subjectBiomarking-
dc.subjectCancer cells-
dc.subjectConfocal microscopy-
dc.subjectFluorescence nanoparticles-
dc.subjectMagnesium oxide-
dc.titleBiocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers-
dc.typeArticle-
dc.identifier.emailDjurisic, AB: dalek@hku.hk-
dc.identifier.authorityDjurisic, AB=rp00690-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/nano9101360-
dc.identifier.pmid31547487-
dc.identifier.pmcidPMC6835516-
dc.identifier.scopuseid_2-s2.0-85073461039-
dc.identifier.hkuros308716-
dc.identifier.volume9-
dc.identifier.issue10-
dc.identifier.spagearticle no. 1360, p. 1-
dc.identifier.epagearticle no. 1360, p. 16-
dc.identifier.isiWOS:000495666800015-
dc.publisher.placeSwitzerland-

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